ArticleProceedings of the National Academy of Sciences of the United States of America2017
Motor control by precisely timed spike patterns.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 136 citations in OpenAlex.
- Diversity-enabled sweet spots in layered architectures and speed-accuracy trade-offs in sensorimotor control.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- A quality measure for repeating multiple-unit spike patterns.Biological cybernetics · 2026Article
- Spiking neurons as predictive controllers of linear systems.PLoS computational biology · 2026Article
- High performance sorting of motor unit action potentials with EMUsort.bioRxiv : the preprint server for biology · 2026Article
- Parsing auditory neural code into maximum-entropy packets.bioRxiv : the preprint server for biology · 2025Article
- Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025Article
- An ion-electronic hybrid artificial neuron with a widely tunable frequency.Nature communications · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- JiSuJi, a virtual muscle for small animal simulations, accurately predicts force from naturalistic spike trains.bioRxiv : the preprint server for biology · 2025Article
- Temporal resolution of spike coding in feedforward networks with signal convergence and divergence.PLoS computational biology · 2025Article
- Respiratory contributions to birdsong-evolutionary considerations and open questions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Millisecond-scale motor coding precedes sensorimotor learning in songbirds.bioRxiv : the preprint server for biology · 2024Article
- Recall tempo of Hebbian sequences depends on the interplay of Hebbian kernel with tutor signal timing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuronal activation sequences in lateral prefrontal cortex encode visuospatial working memory during virtual navigation.Nature communications · 2024Article
- Article
- Daily vocal exercise is necessary for peak performance singing in a songbird.Nature communications · 2023Article
- Myomatrix arrays for high-definition muscle recording.bioRxiv : the preprint server for biology · 2023Article
- Engineering spatiotemporal patterns: information encoding, processing, and controllability in oscillator ensembles.Biomedical physics & engineering express · 2023Article
- An information theoretic method to resolve millisecond-scale spike timing precision in a comprehensive motor program.PLoS computational biology · 2023Article
- A flexible carbon nanotube electrode array for acute in vivo EMG recordings.Journal of neurophysiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
A fundamental problem in neuroscience is understanding how sequences of action potentials ("spikes") encode information about sensory signals and motor outputs. Although traditional theories assume that this information is conveyed by the total number of spikes fired within a specified time interval (spike rate), recent studies have shown that additional information is carried by the millisecond-scale timing patterns of action potentials (spike timing). However, it is unknown whether or how subtle differences in spike timing drive differences in perception or behavior, leaving it unclear whether the information in spike timing actually plays a role in brain function. By examining the activity of individual motor units (the muscle fibers innervated by a single motor neuron) and manipulating patterns of activation of these neurons, we provide both correlative and causal evidence that the nervous system uses millisecond-scale variations in the timing of spikes within multispike patterns to control a vertebrate behavior-namely, respiration in the Bengalese finch, a songbird. These findings suggest that a fundamental assumption of current theories of motor coding requires revision.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.