Evidence map›Paper›PMID 28100486›Full record

ArticleAmerican journal of physiology. Cell physiology2017

c-Jun enhances intestinal epithelial restitution after wounding by increasing phospholipase C-γ1 transcription.

Peng-Yuan Wang, Shelley R Wang, Lan Xiao, Jie Chen, Jian-Ying Wang, Jaladanki N Rao

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Stabilization ofAmerican journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. TRPC1-mediated CaPhysiological reports · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Peng-Yuan WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Shelley R WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jie ChenCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Jaladanki N RaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; rjaladanki@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Intestinal Mucosal Growth in Health & Surgical DiseasesR01DK057819 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2000 to 2026
$7.4M
Surgical Studies of Gut PermeabilityR01DK068491 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Jian-Ying Wang · 2004 to 2026
$7.0M
Mucosal Repair in Gut Surgical DisordersR01DK061972 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, JIAN-YING · 2002 to 2023
$6.7M
REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONI01BX000332 · VA · BALTIMORE VA MEDICAL CENTER · PI Jian-Ying Wang · 2009 to 2026
–
SURGICAL STUDIES ON MUCOSAL HOMEOSTASISI01BX000713 · VA · BALTIMORE VA MEDICAL CENTER · PI WANG, JIAN-YING · 2011 to 2024
–
BLRD VA I01 BX000332BLRD VA I01 BX000713NIDDK NIH HHS R01 DK057819NIDDK NIH HHS R01 DK061972NIDDK NIH HHS R01 DK068491
6 · The paper itself

Abstract

c-Jun is an activating protein 1 (AP-1) transcription factor and implicated in many aspects of cellular functions, but its exact role in the regulation of early intestinal epithelial restitution after injury remains largely unknown. Phospholipase C-γ1 (PLCγ1) catalyzes hydrolysis of phosphatidylinositol 4,5 biphosphate into the second messenger diacylglycerol and inositol 1,4,5 triphosphate, coordinates Ca

Indexed as

AnimalsCalcium SignalingCell LineGene Expression Regulation, EnzymologicIntestinal MucosaIntestinal PerforationPhospholipase C gammaProto-Oncogene Proteins c-junRatsTranscription, GeneticUp-RegulationWound HealingPhospholipase C gammaphospholipase Cgamma1, ratProto-Oncogene Proteins c-junAP-1 gene transcriptionCa2+ influxepithelial restitutionintestinal epithelial cellspolyamines

Identifiers

PMID28100486
PMCPMC5407017
OpenAlexW2573345698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.