ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.
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Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 3% of its field
What it found
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence.Environment international · 2019Pooled it
- Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease.The Journal of physiology · 2026Review
- Decoding type 5 diabetes using spatial omics: microarchitectural and molecular mechanisms of malnutrition-associated diabetes.Frontiers in endocrinology · 2026Review
- Slow-twitch oxidative myofiber proportions and capillary number per myofiber are reduced in growth-restricted fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Histomorphogenesis of human pancreatic islets amidst maternal anaemia: a critical insight.Anatomy & cell biology · 2025Article
- Article
- A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.International journal of molecular sciences · 2025Article
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025Article
- Chronic late gestation fetal hyperglucagonaemia results in lower insulin secretion, pancreatic mass, islet area and beta- and α-cell proliferation.The Journal of physiology · 2024Article
- Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies.American journal of physiology. Endocrinology and metabolism · 2024Article
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.Journal of developmental origins of health and disease · 2023Article
- Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis.Life (Basel, Switzerland) · 2023Article
- Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention.Frontiers in physiology · 2023Review
- Intermittent maternofetal oxygenation during late gestation improved birthweight, neonatal growth, body symmetry, and muscle metabolism in intrauterine growth-restricted lambs.Journal of animal science · 2022Article
- Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction.International journal of molecular sciences · 2021Article
- Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth.The Journal of physiology · 2021Article
- Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.American journal of physiology. Endocrinology and metabolism · 2021Article
- Augmented glucose production is not contingent on high catecholamines in fetal sheep with IUGR.The Journal of endocrinology · 2021Article
- IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.American journal of physiology. Endocrinology and metabolism · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Joshua S BenjaminPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
Christine B CulpepperPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
Laura D BrownPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
Stephanie R WesolowskiPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
Sonnet S JonkerKnight Cardiovascular Institute Center for Developmental Health, Oregon Health & Science University, Portland, Oregon; and.ORCID 0000-0002-1097-2562
Melissa A DavisSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Sean W LimesandSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Randall B WilkeningPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
William W HayPerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado.
Paul J RozancePerinatal Research Center, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado; Paul.Rozance@ucdenver.edu.
University of Colorado Denver · USUniversity of Arizona · USOregon Health & Science University · US
Funding
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0MPILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MUCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5MPrevention of Placental Insufficiency Improves Beta-Cells FunctionR01DK084842 · NIDDK · UNIVERSITY OF ARIZONA · PI SEAN W LIMESAND · 2009 to 2026
$5.6MNutrient Coordination of Pancreatic Vasculature and Beta-CellsR01DK088139 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ROZANCE, PAUL JOSEPH · 2011 to 2020
$5.1MRegulation of Fetal Skeletal Muscle Growth in IUGRR01HD079404 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Laura Davidson Brown · 2015 to 2026
$4.7MNutrient and Insulin Metabolic Actions in IUGR Fetal LiverR01DK108910 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Stephanie R Wesolowski · 2017 to 2026
$4.3MTraining in Basic and Translational Child Health ResearchK12HD068372 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DANIELS, STEPHEN R · 2011 to 2020
$3.7MColorado Clinical and Translational Sciences InstituteKL2TR001080 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$2.6MTISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUSK01DK090199 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WESOLOWSKI, STEPHANIE R · 2010 to 2014
$707kEffect of hypoxia on glucose metabolism in IUGR fetal liverR03DK102972 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WESOLOWSKI, STEPHANIE R · 2014 to 2015
$155kNCATS NIH HHS KL2 TR001080NCATS NIH HHS UL1 TR001082NICHD NIH HHS K12 HD057022NICHD NIH HHS K12 HD068372NICHD NIH HHS R01 HD079404NIDDK NIH HHS K01 DK090199NIDDK NIH HHS R01 DK084842NIDDK NIH HHS R01 DK088139NIDDK NIH HHS R01 DK108910NIDDK NIH HHS R03 DK102972
Abstract
Fetal insulin secretion is inhibited by acute hypoxemia. The relationship between prolonged hypoxemia and insulin secretion, however, is less well defined. To test the hypothesis that prolonged fetal hypoxemia impairs insulin secretion, studies were performed in sheep fetuses that were bled to anemic conditions for 9 ± 0 days (anemic,
Indexed as
AnemiaAnimalsChronic DiseaseDown-RegulationFemaleFetal HypoxiaGlucoseInsulinInsulin SecretionIslets of LangerhansMaleSheepGlucoseInsulinfetusisletoxygenpancreasβ-cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.