Evidence map›Paper›PMID 28100426›Full record

ArticleInternational journal of cardiology2017

Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency.

Kimberly Kallianos, Travis S Henry, Yerem Yeghiazarians, Jeffrey Zimmet, Kendrick A Shunk, Elaine E Tseng, Vaikom Mahadevan, Michael D Hope

Abstract read
In one paragraph

Article in International journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Review
  3. Review
  4. Nanoparticle Diagnostics and Theranostics in the Clinic.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kimberly KallianosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Travis S HenryDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Yerem YeghiazariansDepartment of Cardiology, University of California, San Francisco, United States.
Jeffrey ZimmetDepartment of Cardiology, San Francisco VA Medical Center, United States.
Kendrick A ShunkDepartment of Cardiology, San Francisco VA Medical Center, United States.
Elaine E TsengDepartment of Surgery, San Francisco VA Medical Center, United States.
Vaikom MahadevanDepartment of Cardiology, University of California, San Francisco, United States.
Michael D HopeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States. Electronic address: michael.hope@ucsf.edu.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

Hemodynamic and inflammatory imaging in evaluation of abdominal aortic aneurysmsR01HL123759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOPE, MICHAEL DOUGLAS · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL123759
6 · The paper itself

Abstract

backgroundComputed tomography angiography (CTA) is the test of choice for pre-procedure imaging of transcatheter aortic valve replacement (TAVR) candidates. The iodinated contrast required, however, increases the risk of renal dysfunction in patients with pre-existing renal failure. Ferumoxytol is a magnetic resonance imaging (MRI) contrast agent that can be used with renal failure. Its long vascular resonance time allows gated MRA sequences that approach CTA in image quality. We present respiratory and cardiac gated MRA enabled by ferumoxytol that can be post-processed in an analogous fashion to CTA.

methodsSeven patients with renal failure presenting for TAVR were imaged with respiratory and cardiac gated MRA at 3T using ferumoxtyol for contrast. Aortic annulus, root and peripheral access dimensions were calculated in a fashion identical to that used for CTA. Of these, 6 patients underwent a TAVR procedure and 5 had intraoperative valve assessment with transesophageal echocardiograph (TEE) using standard clinical protocols that employed both two- and three-dimensional techniques.

resultsGood correlation between MRA aortic annulus measurements and those from TEE were shown in 5 patients with mean annulus area of 392.4mm

conclusionsFerumoxytol MRA is a safe alternative to CTA in patients with renal failure for pre-TAVR analysis of the aortic root and peripheral access.

Indexed as

Transcatheter Aortic Valve ReplacementAgedAged, 80 and overAortic ValveFemaleFerrosoferric OxideHeart Valve DiseasesHumansImaging, Three-DimensionalMagnetic Resonance AngiographyMaleMiddle AgedPreoperative PeriodRenal InsufficiencyReproducibility of ResultsFerrosoferric Oxide

Identifiers

PMID28100426
PMCPMC5303665
OpenAlexW2567572599

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.