ArticleAlzheimer's research & therapy2017
A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging.
Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Altered temporal dynamics of prefrontal ERP responses reflecting neural adaptation in patients with amnestic mild cognitive impairment.Alzheimer's research & therapy · 2026Article
- Neurofeedback-Enhanced Working Memory Training: A Proof-of-Concept for Reversing Age-Related Neural Slowing in Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- A Novel Working Memory Task-Induced EEG Response (WM-TIER) Feature Extraction Framework for Detecting Alzheimer's Disease and Mild Cognitive Impairment.Biosensors · 2025Article
- P300 Latency with Memory Performance: A Promising Biomarker for Preclinical Stages of Alzheimer's Disease.Biosensors · 2024Article
- Connectivity changes in two-channel prefrontal ERP associated with early cognitive decline in the elderly population: beta band responses to the auditory oddball stimuli.Frontiers in aging neuroscience · 2024Article
- Reduced Prefrontal-Thalamic Theta Flow During Working Memory Retrieval in APP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2024Article
- Subtle Pathophysiological Changes in Working Memory-Related Potentials and Intrinsic Theta Power in Community-Dwelling Older Adults With Subjective Cognitive Decline.Innovation in aging · 2023Article
- Sharpening Working Memory With Real-Time Electrophysiological Brain Signals: Which Neurofeedback Paradigms Work?Frontiers in aging neuroscience · 2022Review
- Identifying Individuals With Mild Cognitive Impairment Using Working Memory-Induced Intra-Subject Variability of Resting-State EEGs.Frontiers in computational neuroscience · 2021Article
- DelIrium VULnerability in GEriatrics (DIVULGE) study: a protocol for a prospective observational study of electroencephalogram associations with incident postoperative delirium.BMJ neurology open · 2021Article
- Gauging Working Memory Capacity From Differential Resting Brain Oscillations in Older Individuals With A Wearable Device.Frontiers in aging neuroscience · 2021Article
- Memory-Related Frontal Brainwaves Predict Transition to Mild Cognitive Impairment in Healthy Older Individuals Five Years Before Diagnosis.Journal of Alzheimer's disease : JAD · 2021Article
- Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals.PloS one · 2019Article
- Discriminating Fake From True Brain Injury Using Latency of Left Frontal Neural Responses During Old/New Memory Recognition.Frontiers in neuroscience · 2019Article
- Acute Exercise Facilitates the N450 Inhibition Marker and P3 Attention Marker during Stroop Test in Young and Older Adults.Journal of clinical medicine · 2018Article
- Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.Journal of clinical and experimental neuropsychology · 2018Article
- Electrophysiological repetition effects in persons with mild cognitive impairment depend upon working memory demand.Neuropsychologia · 2018Article
- Functional humanAging · 2017Article
- Tuning Up the Old Brain with New Tricks: Attention Training via Neurofeedback.Frontiers in aging neuroscience · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNoninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer's disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.
methodsEighteen NC, 17 subjects with aMCI, and 13 subjects with AD performed a delayed match-to-sample task specially designed not only to be easy enough for impaired participants to complete but also to generate comparable performance between subjects with NC and those with aMCI. Scalp electroencephalography, memory accuracy, and reaction times were measured.
resultsWhereas memory performance separated the AD group from the others, the performance of NC and subjects with aMCI was similar. In contrast, left frontal cognitive ERP patterns differentiated subjects with aMCI from NC. Enhanced P3 responses at left frontal sites were associated with nonmatching relative to matching stimuli during working memory tasks in patients with aMCI and AD, but not in NC. The accuracy of discriminating aMCI from NC was 85% by using left frontal match/nonmatch effect combined with nonmatch reaction time.
conclusionsThe left frontal cognitive ERP indicator holds promise as a sensitive, simple, affordable, and noninvasive biomarker for detection of early cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.