ArticleBMC psychiatry2017
Increased amygdala reactivity following early life stress: a potential resilience enhancer role.
Article in BMC psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Bullying victimization and brain development: a longitudinal structural magnetic resonance imaging study from adolescence to early adulthood.Translational psychiatry · 2026Article
- Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood.bioRxiv : the preprint server for biology · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Genetic risk-dependent brain markers of resilience to childhood Trauma.Nature communications · 2025Article
- Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague-Dawley Rats.Molecular neurobiology · 2025Article
- Early life stress and altered social behaviors: A perspective across species.Neuroscience research · 2025Review
- Epigenetics of Chronic Stress: Mechanisms and Health Impacts.Current genomics · 2025Review
- Emotion Regulation Under Stress: A Social Processing and Memory Perspective.Current topics in behavioral neurosciences · 2025Review
- Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function.bioRxiv : the preprint server for biology · 2024Article
- Child sexual abuse versus adult sexual assault: A review of psychological and neurobiological sequelae.Mental health science · 2024Article
- Functional neuroimaging of resilience to trauma: convergent evidence and challenges for future research.Psychological medicine · 2023Review
- The importance of high quality real-life social interactions during the COVID-19 pandemic.Scientific reports · 2023Article
- Maternal psychological distress associates with alterations in resting-state low-frequency fluctuations and distal functional connectivity of the neonate medial prefrontal cortex.The European journal of neuroscience · 2023Article
- Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.Drug and alcohol dependence reports · 2022Article
- Evaluation of brain structure and metabolism in currently depressed adults with a history of childhood trauma.Translational psychiatry · 2022Article
- Differences in Inhibitory Control and Resting Brain Metabolism between Older Chronic Users of Tetrahydrocannabinol (THC) or Cannabidiol (CBD)-A Pilot Study.Brain sciences · 2022Article
- Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic.Journal of affective disorders · 2022Article
- Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women.Frontiers in psychiatry · 2022Article
- Emotion Regulation as a Pathway Connecting Early Life Adversity and Inflammation in Adulthood: a Conceptual Framework.Adversity and resilience science · 2022Review
- Insula reactivity mediates subjective isolation stress in alexithymia.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundAmygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults.
methodsTwenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS.
resultsMood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall.
conclusionsIncreased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.