ArticleBMC microbiology2017
Interspecies transfer of vancomycin, erythromycin and tetracycline resistance among Enterococcus species recovered from agrarian sources.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 38 citations in OpenAlex.
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- Zooplankton act as cruise ships promoting the survival and pathogenicity of pathogenic bacteria.Microbiology and immunology · 2022Review
- Resistance towards Critically Important Antimicrobials amongAntibiotics (Basel, Switzerland) · 2022Article
- Enterococcal biofilm-A nidus for antibiotic resistance transfer?Journal of applied microbiology · 2022Review
- Genomic Insights ofFrontiers in microbiology · 2022Article
- A Novel Biofilm Model System to Visualise Conjugal Transfer of Vancomycin Resistance by Environmental Enterococci.Microorganisms · 2021Article
- A sampling survey of enterococci within pasteurized, fermented dairy products and their virulence and antibiotic resistance properties.PloS one · 2021Article
- Nisin Influence on the Antimicrobial Resistance Ability of Canine Oral Enterococci.Antibiotics (Basel, Switzerland) · 2020Article
- High-Throughput Detection and Characterization of Antimicrobial ResistantFoods (Basel, Switzerland) · 2020Article
- Competent but complex communication: The phenomena of pheromone-responsive plasmids.PLoS pathogens · 2020Review
- High Level Aminoglycoside Resistance And Distribution Of The Resistance Genes InInfection and drug resistance · 2019Article
- Horizontal transfer ofJournal of animal science and biotechnology · 2019Article
- Genome Comparison of Erythromycin ResistantFrontiers in microbiology · 2017Article
- Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients.Gut microbesArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterococci are now well recognised for their ability to transfer antibiotic resistance and for their association with nosocomial infections, but less is known regarding their relevance in the wider environment. Enterococcus faecalis and Enterococcus faecium were isolated from a range of agrarian associated sources (low-flow water, septic tank, poultry litter, high flow water, slurry/soil) and were assessed for latent ability to transfer antimicrobial resistance.
resultsThe isolates were tested for phenotypic clumping in the presence of cell-free supernatant from other isolates. Some isolates were identified which demonstrated clumping, indicating that they possessed peptide sex pheromone conjugal machinery. All isolates were also tested for antibiotic resistance phenotypes using both disc diffusion and minimum inhibitory concentration (MIC) assays. These tests revealed that the enterococci demonstrated both phenotypic clumping and antibiotic resistance phenotypes. Based on these selection criteria, the isolates were identified as having the potential for horizontal gene transfer and were used to investigate the transfer of multiple antibiotic resistance phenotypes. Conjugal transfer of antibiotic resistance phenotypes was determined using a solid agar mating method followed by a standard antibiotic selection test resulting in different transfer patterns. An interspecies conjugal transfer of vancomycin resistance from E. faecalis to E. faecium was identified while the remaining reactions were within the same species. Transfer efficiencies ranging from 2 × 10
conclusionsThe conjugation reactions and selection conditions used in this study resulted in a variety of co-transferred resistance phenotypes suggesting the presence of different mobile elements in the set of natural isolates. This study highlights the potential for extensive horizontal gene transfer in a previously neglected reservoir for enterococci.
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