ArticleBMC plant biology2017
Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis.
Article in BMC plant biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Molecular mechanisms underlying gene regulatory variation of maize metabolic traits.The Plant cell · 2024Article
- Reveal the kernel dehydration mechanisms in maize based on proteomic and metabolomic analysis.BMC plant biology · 2024Article
- Next generation plant biostimulants & genome sequencing strategies for sustainable agriculture development.Frontiers in microbiology · 2024Review
- Combining association with linkage mapping to dissect the phenolamides metabolism of the maize kernel.Frontiers in plant science · 2024Article
- Asparagine-rich protein (NRP) mediates stress response by regulating biosynthesis of plant secondary metabolites inPlant signaling & behavior · 2023Article
- Gut metabolites produced duringFood chemistry. Molecular sciences · 2022Article
- [A novel method for efficient screening and annotation of important pathway-associated metabolites based on the modified metabolome and probe molecules].Se pu = Chinese journal of chromatography · 2022Article
- Differential Flavonoids and Carotenoids Profiles in Grains of Six Poaceae Crops.Foods (Basel, Switzerland) · 2022Article
- Applications of Genomic Tools in Plant Breeding: Crop Biofortification.International journal of molecular sciences · 2022Review
- Entailing the Next-Generation Sequencing and Metabolome for Sustainable Agriculture by Improving Plant Tolerance.International journal of molecular sciences · 2022Review
- Genetic architecture of inducible and constitutive metabolic profile related to drought resistance in qingke (Tibetan hulless barley).Frontiers in plant science · 2022Article
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
- Transcriptomic Responses ofFrontiers in microbiology · 2021Article
- Transcriptomics and Metabolomics Changes Triggered by Inflorescence Removal inFrontiers in plant science · 2021Article
- Omics Technologies to Enhance Plant Based Functional Foods: An Overview.Frontiers in genetics · 2021Review
- Metabolomics analysis and metabolite-agronomic trait associations using kernels of wheat (Triticum aestivum) recombinant inbred lines.The Plant journal : for cell and molecular biology · 2020Article
- Comparison of Metabolome and Transcriptome of Flavonoid Biosynthesis Pathway in a Purple-Leaf Tea GermplasmInternational journal of molecular sciences · 2020Article
- Comparative transcriptome among Euscaphis konishii Hayata tissues and analysis of genes involved in flavonoid biosynthesis and accumulation.BMC genomics · 2019Article
- Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave.PloS one · 2019Article
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavonoids constitute a diverse class of secondary metabolites which exhibit potent bioactivities for human health and have been indicated to play an important role in plant development and defense. However, accumulation and variation of flavonoid content in diverse maize lines and the genes responsible for their biosynthesis in this important crop remain largely unknown. In this study, we combine genetic mapping, metabolite profiling and gene regulatory network analysis to further enhance understanding of the maize flavonoid pathway.
resultsWe repeatedly detected 25 QTL corresponding to 23 distinct flavonoids across different environments or populations. In addition, a total of 39 genes were revealed both by an expression based network analysis and genetic mapping. Finally, the function of three candidate genes, including two UDP-glycosyltransferases (UGT) and an oxygenase which belongs to the flavone synthase super family, was revealed via preliminary molecular functional characterization.
conclusionWe explored the genetic influences on the flavonoid biosynthesis based on integrating the genomic, transcriptomic and metabolomic information which provided a rich source of potential candidate genes. The integrated genomics based genetic mapping strategy is highly efficient for defining the complexity of functional genetic variants and their respective regulatory networks as well as in helping to select candidate genes and allelic variance before embarking on laborious transgenic validations.
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