Evidence map›Paper›PMID 28100001›Full record

ReviewClinical and experimental immunology2017

Transplantation tolerance: don't forget about the B cells.

A S Chong, S H Khiew

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. CD9Frontiers in immunology · 2018
    Observational
  13. Immune tolerance in transplantation.Clinical and experimental immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

A S ChongSection of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-0460-0196
S H KhiewSection of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA.
University of Chicago · US

Funding

T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
Deconstructing the allo-specific memory B cell responseR01AI110513 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCIAMMAS, ROGER · 2014 to 2017
$1.6M
NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI110513
6 · The paper itself

Abstract

Establishing a state of transplantation tolerance that leads to indefinite graft survival without the need for lifelong immunosuppression has been achieved successfully in limited numbers of transplant recipients in the clinic. These successes led to studies aimed at identifying potential biomarkers that diagnose allograft tolerance and identify the patients most amenable to drug minimization, and implicated an enriched B cell signature of tolerance. The emergence of a specialized subset of regulatory B cell (B

Indexed as

Transplantation ToleranceAnimalsBiomarkersB-Lymphocytes, RegulatoryClonal AnergyGraft RejectionGraft SurvivalHumansImmunosuppression TherapyInterleukin-10Lymphocyte ActivationMiceT-Lymphocytes, RegulatoryBiomarkersInterleukin-10anergybiomarkersBregsIL-10transplantation tolerance

Identifiers

PMID28100001
PMCPMC5508319
OpenAlexW2571885609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.