Evidence map›Paper›PMID 28099946›Full record

ArticleOncotarget2017

Long non-coding RNA ZFAS1 interacts with miR-150-5p to regulate Sp1 expression and ovarian cancer cell malignancy.

Bairong Xia, Yan Hou, Hong Chen, Shanshan Yang, Tianbo Liu, Mei Lin, Ge Lou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bairong XiaDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Yan HouDepartment of Biostatistics, Public Health School, Harbin Medical University, Harbin, China.
Hong ChenDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Shanshan YangDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Tianbo LiuDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Mei LinDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Ge LouDepartment of Gynecology, the Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported that long non-coding RNA ZFAS1 was upregulated in epithelial ovarian cancer tissues, and was negatively correlated to the overall survival rate of patients with epithelial ovarian cancer in this study. While depletion of ZFAS1 inhibited proliferation, migration, and development of chemoresistance, overexpression of ZFAS1 exhibited an even higher proliferation rate, migration activity, and chemoresistance in epithelial ovarian cancer cell lines. We further found miR-150-5p was a potential target of ZFAS1, which was downregulated in epithelial ovarian cancer tissue. MiR-150-5p subsequently inhibited expression of transcription factor Sp1, as evidence by luciferase assays. Inhibition of miR-150-5p rescued the suppressed proliferation and migration induced by depletion of ZFAS1 in epithelial ovarian cancer cells, at least in part. Taken together, our findings revealed a critical role of ZFAS1/miR-150-5p/Sp1 axis in promoting proliferation rate, migration activity, and development of chemoresistance in epithelial ovarian cancer. And ZFAS1/miR-150-5p may serve as novel markers and therapeutic targets of epithelial ovarian cancer.

Indexed as

Gene Expression Regulation, NeoplasticAntineoplastic AgentsApoptosisBiomarkers, TumorCell MovementCell ProliferationCystadenocarcinoma, SerousDrug Resistance, NeoplasmFemaleFollow-Up StudiesHumansMicroRNAsMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingAntineoplastic AgentsBiomarkers, TumorMicroRNAsMIR150, humanSP1 protein, humanSp1 Transcription FactorTranscription FactorsZFAT protein, humanlong non-coding RNAmiR-150-5povarian cancerSp1ZFAS1

Identifiers

PMID28099946
PMCPMC5386703
OpenAlexW2575526604

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.