ArticleOncotarget2017
BI-RADS 3-5 microcalcifications can preoperatively predict breast cancer HER2 and Luminal a molecular subtype.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 38 citations in OpenAlex.
- Ultrasound and immunohistochemical predictors of neoadjuvant chemotherapy response in breast cancer.Translational cancer research · 2025Article
- Imaging Biomarkers for HER2-Positive Breast Cancer: Evidence from an Observational Study.Journal of clinical medicine · 2025Article
- Contrast-enhanced mammography-based interpretable machine learning model for the prediction of the molecular subtype breast cancers.BMC medical imaging · 2025Article
- Contrast-enhanced mammography for breast cancer detection and diagnosis with high concentration iodinated contrast medium.Insights into imaging · 2025Article
- A Multimodal Deep Learning Model for the Classification of Breast Cancer Subtypes.Diagnostics (Basel, Switzerland) · 2025Article
- A prediction model based on dual-layer spectral detector computed tomography for distinguishing nonluminal from luminal invasive breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- Intra- and peritumoral radiomics on assessment of breast cancer molecular subtypes based on mammography and MRI.Journal of cancer research and clinical oncology · 2022Article
- Role of mammogram and ultrasound imaging in predicting breast cancer subtypes in screening and symptomatic patients.World journal of clinical oncology · 2021Article
- Comparison of clinicopathological characteristics and prognosis in breast cancer patients with different Breast Imaging Reporting and Data System categories.Annals of surgical treatment and research · 2021Article
- Contrast-enhanced cone beam breast CT features of breast cancers: correlation with immunohistochemical receptors and molecular subtypes.European radiology · 2021Article
- Clinical and X-ray characteristics for expressions of different receptors in patients with breast cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Mammography features for early markers of aggressive breast cancer subtypes and tumor characteristics: A population-based cohort study.International journal of cancer · 2021Article
- Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score.Radiology research and practice · 2021Article
- The role of endoscopic tumor length in resected esophageal squamous cell carcinoma: a retrospective study.Journal of thoracic disease · 2021Article
- Mammographic tumour appearance is related to clinicopathological factors and surrogate molecular breast cancer subtype.Scientific reports · 2020Article
- Cone-beam breast CT features associated with HER2/neu overexpression in patients with primary breast cancer.European radiology · 2020Article
- Comparison of breast cancer risk factors among molecular subtypes: A case-only study.Cancer medicine · 2019Article
- Association between digital breast tomosynthesis and molecular subtypes of breast cancer.Oncology letters · 2019Article
- Deposition of calcium in an in vitro model of human breast tumour calcification reveals functional role for ALP activity, altered expression of osteogenic genes and dysregulation of the TRPM7 ion channel.Scientific reports · 2019Article
- Diagnostic value of PD-1 mRNA expression combined with breast ultrasound in breast cancer patients.Therapeutics and clinical risk management · 2018Article
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10 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate associations between breast cancer molecular subtype and the patterns of mammographically detected calcifications.
resultsIdentified were 93 (19.1%) Luminal A, 242 (49.9%) Luminal B, 108 (22.2%) HER2 and 42 (8.7%) basal subtypes. In univariate analysis, the clinicopathological parameters and BI-RADS 3-5 microcalcifications, which consisted 9 selected features was significantly associated with breast cancer molecular subtype (all P < 0.05). Among subtypes, multivariate analysis showed that calcification >2 cm in range (OR: 1.878, 95% CI: 1.150 to 3.067) and calcification > 0.5 mm in diameter (OR:2.206, 95% CI: 1.235 to 3.323) was independently predictive of HER2 subtype. The model showed good discrimination for predicting HER2 subtype, with a C-index of 0.704. In addition, multivariate analysis showed that calcification morphology (amorphour or coarse heterogenous calcifications OR: 2.847, 95% CI: 1.526 to 5.312) was independently predictive of Luminal A subtype. The model showed good discrimination for predicting Luminal A subtype, with a C-index of 0.74. And we demonstrated that amorphour or coarse heterogenous calcifications were associated with a higher incidence of Luminal A subtype than pleomorphic or fine linear or branching calcifications. There was no significant difference between breast cancer subtypes (Luminal B vs. other; Basal vs. other) and the patterns of mammographically detected calcifications. MATERIALS AND
methodsMammographic images of 485 female patients were included. The correlation between mammographic imaging features and breast cancer subtype was analyzed using Chi-square test, univariate and binary logistic regression analysis.
conclusionsThis study shows that BI-RADS 3-5 microcalcifications can be conveniently used to facilitate the preoperative prediction of HER2 and Luminal A molecular subtype in patients with infiltrating ductal carcinoma.
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