Evidence map›Paper›PMID 28099644›Full record

ReviewRevista Brasileira de terapia intensiva

Use of biomarkers in pediatric sepsis: literature review.

Vanessa Soares Lanziotti, Pedro Póvoa, Márcio Soares, José Roberto Lapa E Silva, Arnaldo Prata Barbosa, Jorge Ibrain Figueira Salluh

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05311046 (Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool Towards Early Recognition and Personalized Therapeutics), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05311046 not yet recruitingnot on this map

Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool Towards Early Recognition and Personalized Therapeutics

TypeobservationalSponsorComputer Technology Associates, Inc.Ran2026 to 2029Enrolled12,961ConditionsSepsisArmsPediatric sepsis screening tool (either algorithmic or manual)
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Role of biomarkers in pediatric sepsis: What evidence says?World journal of clinical pediatrics · 2026
    Review
  6. Review
  7. Article
  8. Sepsis Prediction: Biomarkers Combined in a Bayesian Approach.International journal of molecular sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Microbiological Profiles and Inflammatory Biomarkers of Bacteremia in Children in a Teaching Hospital in Kuwait: An 8-Year Retrospective Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Article
  15. Review
  16. Presepsin: Hope in the Quest for the Holy Grail.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  17. Article
  18. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Vanessa Soares LanziottiInstituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
Pedro PóvoaNOVA Medical School, Universidade Nova de Lisboa - Lisboa, Portugal.
Márcio SoaresInstituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
José Roberto Lapa E SilvaUniversidade Federal do Rio de Janeiro - Rio de Janeiro (RJ), Brasil.
Arnaldo Prata BarbosaInstituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
Jorge Ibrain Figueira SalluhInstituto D'Or de Pesquisa e Ensino - Rio de Janeiro (RJ), Brasil.
Universidade Federal do Rio de Janeiro · BRD’Or Institute for Research and Education · BRUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

Indexed as

Age FactorsAnti-Bacterial AgentsBiomarkersChildHumansInfantPrognosisSepsisAnti-Bacterial AgentsBiomarkers

Identifiers

PMID28099644
PMCPMC5225923
OpenAlexW2579165064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.