ArticlePloS one2017
Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Behavioral engagement facilitates auditory neuron responses beyond their receptive fields.PLoS biology · 2026Article
- Dynamics of cortical contrast adaptation predict perception of signals in noise.Nature communications · 2023Article
- Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Reversible Inactivation of Ferret Auditory Cortex Impairs Spatial and Nonspatial Hearing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Sound Localization of World and Head-Centered Space in Ferrets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- What can we learn from inactivation studies? Lessons from auditory cortex.Trends in neurosciences · 2022Review
- Effects of Cortical Cooling on Sound Processing in Auditory Cortex and Thalamus of Awake Marmosets.Frontiers in neural circuits · 2021Article
- Synthesis of Hemispheric ITD Tuning from the Readout of a Neural Map: Commonalities of Proposed Coding Schemes in Birds and Mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neurons in primary auditory cortex represent sound source location in a cue-invariant manner.Nature communications · 2019Article
- Sound identity is represented robustly in auditory cortex during perceptual constancy.Nature communications · 2018Article
- Integration of Visual Information in Auditory Cortex Promotes Auditory Scene Analysis through Multisensory Binding.Neuron · 2018Article
- Egocentric and allocentric representations in auditory cortex.PLoS biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to demonstrate the efficacy of acute inactivation of brain areas by cooling in the behaving ferret and to demonstrate that cooling auditory cortex produced a localisation deficit that was specific to auditory stimuli. The effect of cooling on neural activity was measured in anesthetized ferret cortex. The behavioural effect of cooling was determined in a benchmark sound localisation task in which inactivation of primary auditory cortex (A1) is known to impair performance. Cooling strongly suppressed the spontaneous and stimulus-evoked firing rates of cortical neurons when the cooling loop was held at temperatures below 10°C, and this suppression was reversed when the cortical temperature recovered. Cooling of ferret auditory cortex during behavioural testing impaired sound localisation performance, with unilateral cooling producing selective deficits in the hemifield contralateral to cooling, and bilateral cooling producing deficits on both sides of space. The deficit in sound localisation induced by inactivation of A1 was not caused by motivational or locomotor changes since inactivation of A1 did not affect localisation of visual stimuli in the same context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.