ArticleThe journal of trauma and acute care surgery2017
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
Article in The journal of trauma and acute care surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia.Animal models and experimental medicine · 2024Article
- Multicompartmental Trauma Induces Persistent Inflammation and Organ Injury.The Journal of surgical research · 2024Article
- GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol.PloS one · 2023Article
- Ineffective Erythropoietin Response to Anemia in Sepsis.Surgical infections · 2022Article
- Adrenergic Modulation of Erythropoiesis After Trauma.Frontiers in physiology · 2022Review
- Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.The Journal of surgical research · 2021Article
- Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.The journal of trauma and acute care surgery · 2020Observational
- The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress.American journal of surgery · 2020Article
- Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.Shock (Augusta, Ga.) · 2020Article
- Impact of Injury Severity on the Inflammatory State and Severe Anemia.The Journal of surgical research · 2020Observational
- Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.Journal of the American College of Surgeons · 2020Article
- Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.The Journal of surgical research · 2019Article
- Chronic stress induces persistent low-grade inflammation.American journal of surgery · 2019Article
- The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.American journal of respiratory and critical care medicine · 2018Observational
- Persistent injury-associated anemia and aging: Novel insights.The journal of trauma and acute care surgery · 2018Article
- Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation.Toxicology and applied pharmacology · 2018Article
- Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.Frontiers in immunology · 2018Review
- Discrete β-adrenergic mechanisms regulate early and late erythropoiesis in erythropoietin-resistant anemia.Surgery · 2017Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAfter severe trauma, patients develop a norepinephrine-mediated persistent, injury-associated anemia. This anemia is associated with suppression of bone marrow (BM) erythroid colony growth, along with decreased iron levels, and elevated erythropoietin (EPO) levels, which are insufficient to promote effective erythropoiesis. The impact of norepinephrine on iron regulators, such as ferroportin, transferrin, and transferrin receptor-1 (TFR-1), is unknown. Using a clinically relevant rodent model of lung contusion (LC), hemorrhagic shock (HS), and chronic stress (CS), we hypothesize that daily propranolol (BB), a nonselective β blocker, restores BM function and improves iron homeostasis.
methodsMale Sprague-Dawley rats were subjected to LCHS ± BB and LCHS/CS ± BB. BB was achieved with propranolol (10 mg/kg) daily until the day of sacrifice. Hemoglobin, plasma EPO, plasma hepcidin, BM cellularity and BM erythroid colony growth were assessed. RNA was isolated to measure transferrin, TFR-1 and ferroportin expression. Data are presented as mean ± SD; *p < 0.05 versus untreated counterpart by t test.
resultsThe addition of CS to LCHS leads to persistent anemia on posttrauma day 7, while the addition of BB improved hemoglobin levels (LCHS/CS: 10.6 ± 0.8 vs. LCHS/CS + BB: 13.9 ± 0.4* g/dL). Daily BB use after LCHS/CS improved BM cellularity, colony-forming units granulocyte, erythrocyte, monocyte megakaryocyte, burst-forming unit erythroid and colony-forming unit erythroid cell colony growth. LCHS/CS + BB significantly reduced plasma EPO levels and increased plasma hepcidin levels on day 7. The addition of CS to LCHS resulted in decreased liver ferroportin expression as well as decreased BM transferrin and TFR-1 expression, thus, blocking iron supply to erythroid cells. However, daily BB after LCHS/CS improved expression of all iron regulators.
conclusionDaily propranolol administration after LCHS/CS restored BM function and improved anemia after severe trauma. In addition, iron regulators are significantly reduced after LCHS/CS, which may contribute to iron restriction after injury. However, daily propranolol administration after LCHS/CS improved iron homeostasis.
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