Evidence map›Paper›PMID 28099356›Full record

Observational studyMedicine2017

Increased risk of Parkinson disease with diabetes mellitus in a population-based study.

Yu-Wan Yang, Teng-Fu Hsieh, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Jen-Huai Chiang, Tsai-Chung Li, Cheng-Chieh Lin

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 8 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 8 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  8. Pooled it
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Parkinson's disease and glucose metabolism impairment.Translational neurodegeneration · 2025
    Review
  18. Article
  19. Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Yu-Wan YangDepartment of Neurology, China Medical University Hospital School of Medicine, China Medical University Department of Urology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung School of Medicine, Tzu Chi University, Hualian School of Medicine, College of Medicine, China Medical University Department of Medical Research, China Medical University Hospital Department of Family Medicine, China Medical University Hospital Management Office for Health Data, China Medical University Hospital Research Center for Chinese Medicine and Acupuncture, China Medical University Department of Public Health, College of Public Health, China Medical University Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Teng-Fu Hsieh
Chia-Ing Li
Chiu-Shong Liu
Wen-Yuan Lin
Jen-Huai Chiang
Tsai-Chung Li
Cheng-Chieh Lin
China Medical University · CNBuddhist Tzu Chi Medical Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This nationwide population-based study investigated the risk of Parkinson disease (PD) in relation to diabetes mellitus (DM) through the National Health Insurance Research Database in Taiwan.A retrospective study was conducted, consisting of 36,294 patients who were newly diagnosed with DM between January 1, 2000 and December 31, 2006 and 108,882 individuals without DM as healthy controls from insurance claims data from Taiwan's National Health Research Institutes Dataset. The subjects were followed up until December 31, 2011 or until the first manifestation of PD. The hazard ratio (HR) of DM for PD incidence was estimated by Cox proportional hazard regression model.Compared with the non-DM cohort, the incidence density rate of PD was 1.36-fold higher in the DM cohort (1.53 vs 2.08 per 1000 person-years) with an adjusted HR of 1.19 (95% confidence interval = 1.08-1.32) after adjusting for age, sex, comorbidities, and medication use. The adjusted HR of PD for DM with a larger magnitude was observed in females (1.29, 1.12-1.49); individuals age 65 years and older (1.20, 1.06-1.35); those without schizophrenia (1.20, 1.08-1.33), bipolar disorder (1.20, 1.08-1.33), hypertension (1.18, 1.06-1.32), hyperlipidemia (1.21, 1.09-1.34), chronic obstructive pulmonary disease (1.19, 1.06-1.32), coronary artery disease (1.22, 1.09-1.36), stroke (1.23, 1.10-1.37), asthma (1.20, 1.08-1.34), flunarizine use (1.21, 1.08-1.35), zolpidem use (1.16, 1.04-1.30), Charlson comorbidity index score of 0 (1.23, 1.08-1.40), and those using metoclopramide (1.35, 1.14-1.60) and zolpidem (1.46, 1.12-1.90).DM increased the risk of PD during a mean follow-up of 7.3 years. Further mechanistic research on the effect of DM on PD is needed.

Indexed as

AdultAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedParkinson DiseaseRetrospective StudiesRisk FactorsTaiwanYoung Adult

Identifiers

PMID28099356
PMCPMC5279101
OpenAlexW2574386447

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.