Evidence map›Paper›PMID 28099212›Full record

ReviewCurrent opinion in ophthalmology2017

Dysfunctional tear syndrome: dry eye disease and associated tear film disorders - new strategies for diagnosis and treatment.

Mark S Milner, Kenneth A Beckman, Jodi I Luchs, Quentin B Allen, Richard M Awdeh, John Berdahl, Thomas S Boland, Carlos Buznego, Joseph P Gira, Damien F Goldberg and 21 more

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03074344 (Study on the Effectiveness of Eye-drops Containing Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Patients With Mild to Moderate Dry Eye), which is not on this map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03074344 nacompletednot on this map

Study on the Effectiveness of Eye-drops Containing Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Patients With Mild to Moderate Dry Eye

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico "G. Martino"Ran2016 to 2016Enrolled40ConditionsDry Eye SyndromeArmsXLHA+CoQ10, Hyaluronic acid (HA)
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 2 countries.

Mark S MilneraYale University School of Medicine, New Haven bThe Eye Center of Southern Connecticut, Hamden, Connecticut cOhio State University, Columbus dComprehensive Eye Care of Central Ohio, Westerville, Ohio eHofstra Northwell School of Medicine, Hempstead fSouth Shore Eye Care, Wantagh, New York gFlorida Vision Institute, Jupiter hBascom Palmer Eye Institute, Florida International University, and Center for Excellence in Eye Care, Miami, Florida iVance Thompson Vision, Sioux Falls, South Dakota jNortheastern Eye Institute, Scranton kCommonwealth Medical College, Scranton, Pennsylvania lOphthalmology Consultants, St. Louis, Missouri mJules Stein Eye Institute, Los Angeles nWolstan & Goldberg Eye Associates, Torrance, California oPalm Beach Gardens, Florida pRush University Medical Center, Chicago qChicago Eye Specialists rUniversity of Chicago Hospitals, Chicago sJacksoneye, Lake Villa tMidwest Center for Sight, Des Plaines, Illinois uDuke Eye Center, Durham, North Carolina vChicago Cornea Consultants, Ltd, Hoffman Estates, Illinois wWashington University Department of Ophthalmology and Ophthalmology Associates, St. Louis, Missouri xNYU Langone Medical Center, New York, New York yTulane University School of Medicine, New Orleans, Louisiana zOphthalmic Consultants of Long Island, Lynbrook, New York aaThe Center for Ocular Surface Excellence of New Jersey, Woodland Park, New Jersey bbGeorgetown University Medical Center, George Washington University Medical Center, Washington, DC ccNew York Eye and Ear Infirmary of Mount Sinai and Eye Center of New York, New York, New York ddNVision EyeCenters of Newport Beach, Newport Beach, California eeUniversity of Maryland, Baltimore, Maryland ffAdvanced Vision Care, Century City, California ggKeck School of Medicine, University of Southern California, Los Angeles hhBowie Vision Institute, Bowie, Maryland iiUniversity of North Carolina and TLC Laser Eye Centers, Greensboro, North Carolina jjMercy Eye Specialists, Springfield, Missouri kkWake Forest University, Winston-Salem, North Carolina llStorm Eye Institute and Magill Vision Center, Medical University of South Carolina, Charleston mmClemson University, Mt. Pleasant, South Carolina nnUniversity of South Florida, Tampa ooThe Eye Institute of West Florida, Largo, Florida ppCleveland Eye Clinic, Clear Choice Custom LASIK Center, Brecksville, Ohio qqEastern Virginia Medical School and Virginia Eye Consultants, Norfolk, Virginia, USA *Mark S. Milner, Kenneth A. Beckman, and Jodi I. Luchs are co-chairs.
Kenneth A Beckman
Jodi I Luchs
Quentin B Allen
Richard M Awdeh
John Berdahl
Thomas S Boland
Carlos Buznego
Joseph P Gira
Damien F Goldberg
David Goldman
Raj K Goyal
Mitchell A Jackson
James Katz
Terry Kim
Parag A Majmudar
Ranjan P Malhotra
Marguerite B McDonald
Rajesh K Rajpal
Tal Raviv
Sheri Rowen
Neda Shamie
Jonathan D Solomon
Karl Stonecipher
Shachar Tauber
William Trattler
Keith A Walter
George O Waring
Robert J Weinstock
William F Wiley
Elizabeth Yeu
Florida International University · USNortheastern Eye Institute · USSouth Shore Eye Care · USThe Ohio State University · USVance Thompson Vision · USWolstan & Goldberg Eye Associates · USBowie State University · USChicago Cornea Consultants (United States) · USCleveland Eye Clinic · USMedical University of South Carolina · USMidwest Eye Center · USOphthalmic Consultants of Long Island · USOphthalmology Associates (United States) · USOphthalmology Consultants · USPalm Beach Gardens Medical Center · USRush University Medical Center · USUniversity of Chicago · USUniversity of Maryland, Baltimore · USVirginia Eye Consultants · USVision Eye Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunctional tear syndrome (DTS) is a common and complex condition affecting the ocular surface. The health and normal functioning of the ocular surface is dependent on a stable and sufficient tear film. Clinician awareness of conditions affecting the ocular surface has increased in recent years because of expanded research and the publication of diagnosis and treatment guidelines pertaining to disorders resulting in DTS, including the Delphi panel treatment recommendations for DTS (2006), the International Dry Eye Workshop (DEWS) (2007), the Meibomian Gland Dysfunction (MGD) Workshop (2011), and the updated Preferred Practice Pattern guidelines from the American Academy of Ophthalmology pertaining to dry eye and blepharitis (2013). Since the publication of the existing guidelines, new diagnostic techniques and treatment options that provide an opportunity for better management of patients have become available. Clinicians are now able to access a wealth of information that can help them obtain a differential diagnosis and treatment approach for patients presenting with DTS. This review provides a practical and directed approach to the diagnosis and treatment of patients with DTS, emphasizing treatment that is tailored to the specific disease subtype as well as the severity of the condition.

Indexed as

Dry Eye SyndromesBlepharitisEyelid DiseasesHumansKeratoconjunctivitis SiccaMeibomian GlandsTears

Identifiers

PMID28099212
PMCPMC5345890
OpenAlexW2579271585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.