Evidence map›Paper›PMID 28098782›Full record

ArticleToxins2017

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication.

Stefan Carle, Thorsten Brink, Joachim H C Orth, Klaus Aktories, Holger Barth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stefan CarleInstitute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, Ulm 89081, Germany. stefan.carle@uni-ulm.de.
Thorsten BrinkInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany. thorsten.brink@pharmakol.uni-freiburg.de.
Joachim H C OrthInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany. joachim.orth@pharmakol.uni-freiburg.de.
Klaus AktoriesInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany. klaus.aktories@pharmakol.uni-freiburg.de.
Holger BarthInstitute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, Ulm 89081, Germany. holger.barth@uni-ulm.de.
University of Freiburg · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The AB-type protein toxin from

Indexed as

AuranofinBacterial ProteinsBacterial ToxinsCatalytic DomainCell Culture TechniquesCytosolHeLa CellsHeterotrimeric GTP-Binding ProteinsHost-Pathogen InteractionsHumansPasteurella multocidaThioredoxin-Disulfide ReductaseVirulenceAuranofinBacterial ProteinsBacterial ToxinsHeterotrimeric GTP-Binding ProteinsPasteurella multocida toxinThioredoxin-Disulfide ReductaseauranofindeamidationG-proteinPasteurella multocida toxin (PMT)thioredoxin reductase (TrxR)

Identifiers

PMID28098782
PMCPMC5308264
OpenAlexW2575556249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.