Evidence map›Paper›PMID 28098781›Full record

ArticleToxins2017

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.

Jana Maurer, Sabrina Hupp, Carolin Bischoff, Christina Foertsch, Timothy J Mitchell, Trinad Chakraborty, Asparouh I Iliev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Jana MaurerDFG Membrane/Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology & Rudolf Virchow Center for Experimental Biomedical Science, University of Würzburg, Versbacherstr. 9, 97078 Würzburg, Germany. jana_maurer@t-online.de.
Sabrina HuppDFG Membrane/Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology & Rudolf Virchow Center for Experimental Biomedical Science, University of Würzburg, Versbacherstr. 9, 97078 Würzburg, Germany. sabrina.hupp@ana.unibe.ch.
Carolin BischoffDFG Membrane/Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology & Rudolf Virchow Center for Experimental Biomedical Science, University of Würzburg, Versbacherstr. 9, 97078 Würzburg, Germany. carolin_bischoff@gmx.de.
Christina FoertschDFG Membrane/Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology & Rudolf Virchow Center for Experimental Biomedical Science, University of Würzburg, Versbacherstr. 9, 97078 Würzburg, Germany. christina.foertsch@pharmalex.com.
Timothy J MitchellChair of Microbial Infection and Immunity, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. t.j.mitchell@bham.ac.uk.
Trinad ChakrabortyInstitute for Medical Microbiology, University of Giessen, Schubertstr. 81, 35392 Giessen, Germany. trinad.chakraborty@mikrobio.med.uni-giessen.de.
Asparouh I IlievDFG Membrane/Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology & Rudolf Virchow Center for Experimental Biomedical Science, University of Würzburg, Versbacherstr. 9, 97078 Würzburg, Germany. asparouh.iliev@ana.unibe.ch.
University of Bern · CHUniversity of Würzburg · DEHeidelberg University · DEJustus-Liebig-Universität Gießen · DEUniversity of Birmingham · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores. Some effects of the toxins are observed in non-lytic concentrations. Two pathogens,

Indexed as

AnimalsAnimals, NewbornAstrocytesBacterial ProteinsBacterial ToxinsBrainCell Membrane PermeabilityCells, CulturedCell ShapeCell SurvivalDendritic SpinesHeat-Shock ProteinsHemolysin ProteinsListeria monocytogenesMice, Inbred C57BLNeurotoxinsBacterial ProteinsBacterial ToxinsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesNeurotoxinsplY protein, Streptococcus pneumoniaeRecombinant ProteinsStreptolysinsacute slicesdendritic spineslisteriolysin Omeningitisvaricosities

Identifiers

PMID28098781
PMCPMC5308266
OpenAlexW2577457211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.