Evidence map›Paper›PMID 28098777›Full record

ArticleInternational journal of molecular sciences2017

New Irradiation Method with Indocyanine Green-Loaded Nanospheres for Inactivating Periodontal Pathogens.

Yasuyuki Sasaki, Jun-Ichiro Hayashi, Takeki Fujimura, Yuki Iwamura, Genta Yamamoto, Eisaku Nishida, Tasuku Ohno, Kosuke Okada, Hiromitsu Yamamoto, Takeshi Kikuchi and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Impact of Molar Furcations on Photodynamic Therapy Outcomes: A 6-Month Split-Mouth Randomized Clinical Trial.International journal of environmental research and public health · 2020
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  10. Engineering Polymeric Nanosystems against Oral Diseases.Molecules (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yasuyuki SasakiDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. ag143d09@dpc.agu.ac.jp.
Jun-Ichiro HayashiDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. jun1row@dpc.agu.ac.jp.
Takeki FujimuraDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. takeki@dpc.agu.ac.jp.
Yuki IwamuraDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. yukiwa@dpc.agu.ac.jp.
Genta YamamotoDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. genta@dpc.agu.ac.jp.
Eisaku NishidaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. enishida@dpc.agu.ac.jp.
Tasuku OhnoDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. ag143d03@dpc.agu.ac.jp.
Kosuke OkadaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. ag133d03@dpc.agu.ac.jp.
Hiromitsu YamamotoDepartment of Pharmaceutical Engineering, School of Pharmacology, Aichi Gakuin University, Nagoya, Aichi 464-8650, Japan. hiromitu@dpc.agu.ac.jp.
Takeshi KikuchiDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. tkikuchi@dpc.agu.ac.jp.
Akio MitaniDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. minita@dpc.agu.ac.jp.
Mitsuo FukudaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan. fukuda-m@dpc.agu.ac.jp.
Aichi Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive strategy for periodontitis treatments. However, use of aPDT for periodontal treatment is complicated by the difficulty in accessing morphologically complex lesions such as furcation involvement, which the irradiation beam (which is targeted parallel to the tooth axis into the periodontal pocket) cannot access directly. The aim of this study was to validate a modified aPDT method that photosensitizes indocyanine green-loaded nanospheres through the gingivae from outside the pocket using a diode laser. To establish this trans-gingival irradiation method, we built an in vitro aPDT model using a substitution for gingivae. Irradiation conditions and the cooling method were optimized before the bactericidal effects on

Indexed as

Lasers, SemiconductorAbsorption, RadiationAnti-Bacterial AgentsCold TemperatureHumansIndocyanine GreenMicrobial ViabilityModels, BiologicalNanospheresPeriodontitisPermeabilityPhotochemotherapyPhotosensitizing AgentsPorphyromonas gingivalisAnti-Bacterial AgentsIndocyanine GreenPhotosensitizing Agentsdiode laserindocyanine greenphotodynamic therapy

Identifiers

PMID28098777
PMCPMC5297787
OpenAlexW2576368165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.