ArticleeLife2017
Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- Pvr and Pvf2 Are Essential for Valve Cell Differentiation in the Larval Drosophila Heart.Genesis (New York, N.Y. : 2000) · 2026Article
- The ultrastructural characterization and immunophenotypic features of telocytes in the myocardium and aortic bulb of young and adult Tibetan sheep.BMC veterinary research · 2026Article
- Coordination of cardiogenesis in vivo and in vitro.Nature reviews. Molecular cell biology · 2026Review
- Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish.PLoS biology · 2025Article
- Custom 3D-Printed Molds for Zebrafish Imaging and Cardiac Development.Journal of visualized experiments : JoVE · 2025Article
- A method for creating custom 3D-printed molds to facilitate zebrafish imaging studies, including of cardiac development.bioRxiv : the preprint server for biology · 2025Article
- PDGFRA is a conserved HAND2 effector during early cardiac development.Nature cardiovascular research · 2024Article
- Article
- Formation of the Heart: Defining Cardiomyocyte Progenitors at Single-Cell Resolution.Current cardiology reports · 2023Review
- The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation.bioRxiv : the preprint server for biology · 2023Article
- Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal transition in regenerating pig hearts.Frontiers in bioengineering and biotechnology · 2023Article
- A SOX17-PDGFB signaling axis regulates aortic root development.Nature communications · 2022Article
- Review
- Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.Nature communications · 2022Article
- Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy.Science advances · 2022Article
- Profiling Genome-Wide DNA Methylation Patterns in Human Aortic and Mitral Valves.Frontiers in cardiovascular medicine · 2022Article
- Using Live Imaging to Examine Early Cardiac Development in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Of form and function: Early cardiac morphogenesis across classical and emerging model systems.Seminars in cell & developmental biology · 2021Review
- Toward a broader view of mechanisms of drug cardiotoxicity.Cell reports. Medicine · 2021Review
- PDGFRα: Expression and Function during Mitral Valve Morphogenesis.Journal of cardiovascular development and disease · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Communication between neighboring tissues plays a central role in guiding organ morphogenesis. During heart tube assembly, interactions with the adjacent endoderm control the medial movement of cardiomyocytes, a process referred to as cardiac fusion. However, the molecular underpinnings of this endodermal-myocardial relationship remain unclear. Here, we show an essential role for platelet-derived growth factor receptor alpha (Pdgfra) in directing cardiac fusion. Mutation of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.