Evidence map›Paper›PMID 28098186›Full record

ArticleScientific reports2017

A novel multi-target regression framework for time-series prediction of drug efficacy.

Haiqing Li, Wei Zhang, Ying Chen, Yumeng Guo, Guo-Zheng Li, Xiaoxin Zhu

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haiqing LiDepartment of Control Science and Engineering, Tongji University, Shanghai, 201804, China.
Wei ZhangDepartment of Control Science and Engineering, Tongji University, Shanghai, 201804, China.
Ying ChenInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100700, China.
Yumeng GuoDepartment of Control Science and Engineering, Tongji University, Shanghai, 201804, China.
Guo-Zheng LiDepartment of Control Science and Engineering, Tongji University, Shanghai, 201804, China.
Xiaoxin ZhuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excavating from small samples is a challenging pharmacokinetic problem, where statistical methods can be applied. Pharmacokinetic data is special due to the small samples of high dimensionality, which makes it difficult to adopt conventional methods to predict the efficacy of traditional Chinese medicine (TCM) prescription. The main purpose of our study is to obtain some knowledge of the correlation in TCM prescription. Here, a novel method named Multi-target Regression Framework to deal with the problem of efficacy prediction is proposed. We employ the correlation between the values of different time sequences and add predictive targets of previous time as features to predict the value of current time. Several experiments are conducted to test the validity of our method and the results of leave-one-out cross-validation clearly manifest the competitiveness of our framework. Compared with linear regression, artificial neural networks, and partial least squares, support vector regression combined with our framework demonstrates the best performance, and appears to be more suitable for this task.

Indexed as

Medicine, Chinese TraditionalNeural Networks, ComputerRegression AnalysisAlgorithms

Identifiers

PMID28098186
PMCPMC5241636

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.