Evidence map›Paper›PMID 28098162›Full record

SynthesisNature communications2017

Novel genetic loci associated with hippocampal volume.

Derrek P Hibar, Hieab H H Adams, Neda Jahanshad, Ganesh Chauhan, Jason L Stein, Edith Hofer, Miguel E Renteria, Joshua C Bis, Alejandro Arias-Vasquez, M Kamran Ikram and 322 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  18. HiFiMAP: High-resolution fast identity-by-descent mapping test.medRxiv : the preprint server for health sciences · 2026
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

332 authors.

Derrek P HibarImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Hieab H H AdamsDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Neda JahanshadImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Ganesh ChauhanINSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.
Jason L SteinImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Edith HoferDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Miguel E RenteriaQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Avenue/Suite 1360. Seattle, Washington 98101, USA.
Alejandro Arias-VasquezDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
M Kamran IkramDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Sylvane DesrivièresMRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Meike W VernooijDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Lucija AbramovicBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Saud AlhusainiDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Micael AnderssonDepartment of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
Benjamin S AribisalaBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Nicola J ArmstrongCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Lavinia AthanasiuNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
Tomas AxelssonDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Box 1432, SE-751 44 Uppsala, Sweden.
Ashley H BeechamDr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
Alexa BeiserDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.
Manon BernardHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8.
Susan H BlantonDr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
Marc M BohlkenBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Marco P BoksBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-6163-7484
Janita BraltenDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center, 639 West 1168th Street, New York, New York 10032, USA.
Owen CarmichaelPennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Quebec, Canada H4H 1R3.
Qiang ChenLieber Institute for Brain Development, Baltimore, Maryland 21205, USA.
Christopher R K ChingImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Vincent ChourakiDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.
Gabriel Cuellar-PartidaQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Fabrice CrivelloIMN UMR5293, GIN, CNRS, CEA, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.
Anouk Den BraberBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Nhat Trung DoanNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307 Dresden, Germany.
Sudheer GiddaluruNORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
Aaron L GoldmanLieber Institute for Brain Development, Baltimore, Maryland 21205, USA.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Oliver GrimmCentral Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, 68159 Mannheim, Germany.
Michael E GriswoldDepartment of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, 39216, USA.
Tulio GuadalupeLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, The Netherlands.
Boris A GutmanImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Johanna HassDepartment of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, 01307 Dresden, Germany.
Unn K HaukvikNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
David HoehnMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Avram J HolmesDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Martine HoogmanDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Deborah JanowitzDepartment of Psychiatry, University Medicine Greifswald, 17489 Greifswald, Germany.
Tianye JiaMRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.ORCID 0000-0001-5399-2953
Kjetil N JørgensenNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
Nazanin KarbalaiMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Dalia KasperaviciuteUCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, SL9 0RJ, UK.
Sungeun KimCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Marieke KleinDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-8784-5679
Bernd KraemerSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, 69120, Germany.
Phil H LeeDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
David C M LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Lorna M LopezCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Christine MacareMRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Andre F MarquandDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
Mar MatarinUCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, SL9 0RJ, UK.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Manuel MattheisenDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark.ORCID 0000-0002-8442-493X
David R McKayDepartment of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.
Yuri MilaneschiDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, 1081 HL Amsterdam, The Netherlands.
Susana Muñoz ManiegaBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Kwangsik NhoCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Allison C NugentHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
Paul NyquistDepartment of Neurology, Department of Anesthesia/Critical Care Medicine, Department of Neurosurgery, Johns Hopkins, USA600 N. Wolfe St, Baltimore, Maryland 21287, USA.
Loes M Olde LoohuisCenter for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA.ORCID 0000-0002-3327-7837
Jaap OosterlaanDepartment of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, 1081 HV, The Netherlands.
Martina PapmeyerDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
Lukas PirpamerDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Benno PützMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Adaikalavan RamasamyReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Jennifer S RichardsDepartment of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Shannon L RisacherCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Roberto Roiz-SantiañezDepartment of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008 Santander, Spain.
Nanda RommelseDepartment of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Stefan RopeleDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Emma J RosePsychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College, Dublin, Dublin 2, Ireland.
Natalie A RoyleBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Tatjana RundekDepartment of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
Philipp G SämannMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Arvin SaremiImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Claudia L SatizabalDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.ORCID 0000-0002-1115-4430
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, 3502, Australia.
Andrew J SchorkMultimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, California 92093, USA.
Li ShenCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.ORCID 0000-0002-5443-0503
Jean ShinHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8.
Elena ShumskayaDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Albert V SmithIcelandic Heart Association, Kopavogur, 201, Iceland.
Emma SprootenDepartment of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.
Lachlan T StrikeQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-8309-094X
Diana Tordesillas-GutierrezCIBERSAM (Centro Investigación Biomédica en Red Salud Mental), Santander, 39011, Spain.
Roberto ToroInstitut Pasteur, 75015 Paris, France.
Daniah TrabzuniReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.ORCID 0000-0003-4826-9570
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
Dhananjay VaidyaGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
Jeroen Van der GrondDepartment of Radiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
Sven J Van der LeeDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.ORCID 0000-0003-1606-8643
Dennis Van der MeerDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
Marjolein M J Van DonkelaarDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Kristel R Van EijkBrain Center Rudolf Magnus, Human Neurogenetics Unit, UMC Utrecht, 3584 CG Utrecht, The Netherlands.
Theo G M Van ErpDepartment of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California 92617, USA.
Daan Van RooijDepartment of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Esther WaltonDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307 Dresden, Germany.
Lars T WestlyeNORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0001-8644-956X
Christopher D WhelanImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
Beverly G WindhamNORMENT-KG Jebsen Centre, Department of Psychology, University of Oslo, 0317 Oslo, Norway.
Anderson M WinklerDepartment of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.ORCID 0000-0002-4169-9781
Katharina WittfeldDepartment of Psychiatry, University Medicine Greifswald, 17489 Greifswald, Germany.
Girma WoldehawariatHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
Christiane WolfGerman Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 17487 Greifswald, Germany.
Thomas WolfersDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Lisa R YanekGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Alex ZijdenbosDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.
Marcel P ZwiersDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
Ingrid AgartzNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
Laura AlmasyDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
David AmesDepartment of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 29104, USA.
Philippe AmouyelLille University, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France.ORCID 0000-0001-9088-234X
Ole A AndreassenNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.ORCID 0000-0002-4461-3568
Sampath ArepalliAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Amelia A AssarehCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Sandra BarralTaub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center, 639 West 1168th Street, New York, New York 10032, USA.
Mark E BastinBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Diane M BeckerGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St Suite 8028, Baltimore, Maryland 21287, USA.
James T BeckerLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
John BlangeroDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Hans van BokhovenDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Dorret I BoomsmaBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0001-9487-6617
Rachel M BrouwerBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Han G BrunnerDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Randy L BucknerDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Kazima B BulayevaDepartment of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA.
Wiepke CahnBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Vince D CalhounDepartment of Evolution and Genetics, Dagestan State University, Makhachkala 367000, Dagestan, Russia.
Dara M CannonHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
Gianpiero L CavalleriThe Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Ching-Yu ChengAcademic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.
Sven CichonDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.
Mark R CooksonAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Aiden CorvinPsychosis Research Group, Department of Psychiatry & Trinity Translational Medicine Institute, Trinity College, Dublin, Dublin 2, Ireland.
Benedicto Crespo-FacorroDepartment of Medicine and Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, 39008 Santander, Spain.
Joanne E CurranDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Michael CzischMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Anders M DaleInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany.
Gareth E DaviesDepartments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, California 92093, USA.
Anton J M De CraenAvera Institute for Human Genetics, Sioux Falls, South Dakota 57108, USA.
Eco J C De GeusBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Philip L De JagerHarvard Medical School, Boston, Massachusetts 02115, USA.
Greig I De ZubicarayBroad Institute, Cambridge, Massachusetts, 02142, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Stéphanie DebetteINSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.
Charles DeCarliDepartment of Neurology, Bordeaux University Hospital, Bordeaux, 33076, France.
Norman DelantyThe Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Chantal DepondtNeurology Division, Beaumont Hospital, Dublin 9, Ireland.
Anita DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118 USA.
Allissa DillmanAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Srdjan DjurovicNORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
Gary DonohoeDepartment of Medical Genetics, Oslo University Hospital, 0420 Oslo, Norway.
Wayne C DrevetsHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
Ravi DuggiralaDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Thomas D DyerDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0002-5809-1190
Christian EnzingerDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Susanne ErkJanssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
Thomas EspesethNORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.
Iryna O FedkoBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Guillén FernándezDepartment of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Luigi FerrucciCharité - Universitätsmedizin Berlin, Campus Charité Mitte, Department of Psychiatry and Psychotherapy, Charitéplatz 1, 10117 Berlin, Germany.
Simon E FisherDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-3132-1996
Debra A FleischmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Ian FordDepartment of Neurological Sciences & Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois 60616, USA.
Myriam FornageRobertson Centre for Biostatistics, University of Glasgow, Glasgow, G41 4DQ, UK.
Tatiana M ForoudIndiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Peter T FoxMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Clyde FrancksDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
Masaki FukunagaUniversity of Texas Health Science Center, San Antonio, Texas 78229, USA.
J Raphael GibbsReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
David C GlahnDepartment of Psychiatry, Yale University, New Haven, Connecticut 06511, USA.
Randy L GollubDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Harald H H GöringDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Robert C GreenHarvard Medical School, Boston, Massachusetts 02115, USA.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, 69120, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, 201, Iceland.
Sebastian GuelfiReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Asta K HåbergDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Narelle K HansellQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
John HardyReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
Ryota HashimotoDepartment of Radiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, 7030, Norway.ORCID 0000-0002-5941-4238
Katrin HegenscheidMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, 565-0871, Japan.
Andreas HeinzJanssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
Stephanie Le HellardNORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
Dena G HernandezReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Dirk J HeslenfeldGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, 72076, Germany.
Beng-Choon HoDepartment of Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands.ORCID 0000-0003-3976-1555
Pieter J HoekstraDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands.
Wolfgang HoffmannInstitute for Community Medicine, University Medicine Greifswald, 17489 Greifswald, Germany.
Albert HofmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115 USA.
Florian HolsboerMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Georg HomuthDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115 USA.
Norbert HostenMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, 565-0871, Japan.
Jouke-Jan HottengaBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Matthew HuentelmanHMNC Brain Health, Munich, 80539, Germany.
Hilleke E Hulshoff PolBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Masashi IkedaInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17489 Greifswald, Germany.
Clifford R JackTranslational Genomics Research Institute, Neurogenomics Division, 445N Fifth Street, Phoenix, Arizona 85004, USA.
Mark JenkinsonDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, 39216, USA.
Robert JohnsonDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Erik G JönssonNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
René S KahnBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Ryota KanaiDepartment of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Iwona KloszewskaInstitute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK.
David S KnopmanDepartment of Neuroinformatics, Araya Brain Imaging, Tokyo, 102-0093, Japan.
Peter KochunovMedical University of Lodz, 90-419 Lodz, Poland.
John B KwokDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA.
Stephen M LawrieDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
Hervé LemaîtreNeuroscience Research Australia, Sydney, New South Wales 2031, Australia.
Xinmin LiuHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.
Dan L LongoINSERM UMR 1000 "Neuroimaging and Psychiatry", Service Hospitalier Frédéric Joliot; University Paris-Sud, Université Paris-Saclay, University Paris Descartes, Maison de Solenn, Paris, 91400, France.
Oscar L LopezColumbia University Medical Center, New York, New York 10032, USA.
Simon LovestoneLaboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Oliver MartinezDepartment of Neurology, Bordeaux University Hospital, Bordeaux, 33076, France.
Jean-Luc MartinotNeuroscience Research Australia, Sydney, New South Wales 2031, Australia.
Venkata S MattayLieber Institute for Brain Development, Baltimore, Maryland 21205, USA.
Colm McDonaldDepartment of ECE, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Andrew M McIntoshCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.ORCID 0000-0002-0198-4588
Francis J McMahonHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, 35 Convent Drive, Rm 1A202, Bethesda, Maryland 20892-3719, USA.ORCID 0000-0002-9469-305X
Katie L McMahonDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Patrizia MecocciCentre for Advanced Imaging, University of Queensland, Brisbane, Queensland 4072, Australia.
Ingrid MelleNORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
Andreas Meyer-LindenbergCentral Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, 68159 Mannheim, Germany.
Sebastian MohnkeJanssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Derek W MorrisDepartment of Medical Genetics, Oslo University Hospital, 0420 Oslo, Norway.
Thomas H MosleyNORMENT-KG Jebsen Centre, Department of Psychology, University of Oslo, 0317 Oslo, Norway.
Thomas W MühleisenDivision of Medical Genetics, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Michael A NallsAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Matthias NauckUniversity of Liverpool, Institute of Translational Medicine, Liverpool L69 3BX, UK.
Thomas E NicholsDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, 39216, USA.ORCID 0000-0002-4516-5103
Wiro J NiessenDepartment of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
Markus M NöthenDivision of Medical Genetics, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.
Lars NybergDepartment of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
Kazutaka OhiDepartment of Radiology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, 7030, Norway.
Rene L OlveraMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Roel A OphoffBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Massimo PandolfoNeurology Division, Beaumont Hospital, Dublin 9, Ireland.
Tomas PausDepartment of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
Zdenka PausovaHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8.
Brenda W J H PenninxDepartment of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
G Bruce PikeDepartments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2.ORCID 0000-0001-8924-683X
Steven G PotkinDepartment of Psychiatry and Human Behavior, University of California-Irvine, Irvine, California 92617, USA.
Bruce M PsatyDepartment of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Simone ReppermundCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Marcella RietschelCentral Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, 68159 Mannheim, Germany.
Joshua L RoffmanDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nina Romanczuk-SeiferthJanssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
Jerome I RotterDepartment of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Mina RytenReta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK.
Ralph L SaccoJohn P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0002-9595-3220
Andrew J SaykinCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.ORCID 0000-0002-1376-8532
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Helena SchmidtNeuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.
Peter R SchofieldDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA.ORCID 0000-0003-2967-9662
Sigurdur SigurssonIcelandic Heart Association, Kopavogur, 201, Iceland.
Andrew SimmonsInstitute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21/III, 8010 Graz, Austria.
Andrew SingletonAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Sanjay M SisodiyaUCL Institute of Neurology, London, United Kingdom and Epilepsy Society, Bucks, SL9 0RJ, UK.
Colin SmithBiomedical Research Unit for Dementia, King's College London, London SE5 8AF, UK.
Jordan W SmollerDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Hilkka SoininenMRC Edinburgh Brain Bank, University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences, Edinburgh, EH16 4SB UK.
Vidar M SteenNORMENT-KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.
David J StottNeurocentre Neurology, Kuopio University Hospital, FI-70211 Kuopio, Finland.
Jessika E SussmannDivision of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Arthur W TogaInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, G4 0SF, UK.
Bryan J TraynorAcademic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria 3101, Australia.
Juan TroncosoLaboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA.
Magda TsolakiDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Christophe TzourioINSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.
Andre G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Maria C Valdés HernándezBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
Marcel Van der BrugDepartment of Internal Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
Aad van der LugtDepartment of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
Nic J A van der WeeGenentech Inc., South San Francisco, California 94080, USA.
Neeltje E M Van HarenBrain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
Dennis van 't EntBiological Psychology, Amsterdam Neuroscience, Vrije Universiteit & Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands.
Marie-Jose Van TolDepartment of Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Badri N VardarajanTaub Institute for Research on Alzheimer's Disease and the Aging Brain; G.H. Sergievsky Center; Department of Neurology. Columbia University Medical Center, 639 West 1168th Street, New York, New York 10032, USA.
Bruno VellasUniversity of Groningen, University Medical Center Groningen, Department of Neuroscience, 9713 AW Groningen, the Netherlands.
Dick J VeltmanDepartment of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, 17489 Greifswald, Germany.
Henrik WalterJanssen Research & Development, LLC, Titusville, New Jersey 08560, USA.
Joanna M WardlawBrain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-9812-6642
Thomas H WassinkDepartment of Internal Medicine and Geriatric Medicine, INSERM U1027, University of Toulouse, Toulouse, 31024, France.
Michael E WealeDepartment of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK.
Daniel R WeinbergerLieber Institute for Brain Development, Baltimore, Maryland 21205, USA.
Michael W WeinerDepartments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
Eric WestmanCenter for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, California 94121, USA.ORCID 0000-0002-3115-2977
Tonya WhiteDepartment of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
Tien Y WongAcademic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.
Clinton B WrightDepartment of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
Ronald H ZielkeDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Alan B ZondermanDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, 3015 CE Rotterdam, The Netherlands.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Cornelia M Van DuijnDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
W T LongstrethLaboratory of Epidemiology & Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Gunter SchumannMRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Hans J GrabeDepartment of Psychiatry, University Medicine Greifswald, 17489 Greifswald, Germany.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4375-6572
Lenore J LaunerDepartments of Neurology and Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, Washington 98104-2420, USA.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.
Paul M ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Medical Research Council G0701120Medical Research Council G0802462Medical Research Council G0900908Medical Research Council G0901858Medical Research Council G1001245Medical Research Council MC_UU_12013/2Medical Research Council MR/K01417X/1Medical Research Council MR/K026992/1Medical Research Council MR/L016400/1Medical Research Council MR/M013111/1Medical Research Council MR/N008324/1NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG040039NIA NIH HHS R01 AG040060NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG041915NIA NIH HHS U01 AG049505NIBIB NIH HHS U54 EB020403NIMH NIH HHS K01 MH099232NIMH NIH HHS R00 MH101367NIMH NIH HHS R00 MH102357NIMH NIH HHS R01 MH042191NIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH083824NIMH NIH HHS R01 MH090553NIMH NIH HHS T32 MH073526NINDS NIH HHS R01 NS017950NINDS NIH HHS T32 NS048004NLM NIH HHS R00 LM011384NLM NIH HHS R01 LM012535Wellcome Trust 104036
6 · The paper itself

Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r

Indexed as

AdolescentAdultAgedAged, 80 and overAlzheimer DiseaseChildCohort StudiesDipeptidyl Peptidase 4FemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGlycoproteinsHippocampusHumansMaleASTN2 protein, humanDipeptidyl Peptidase 4DPP4 protein, humanGlycoproteinsMAST4 protein, humanMethionine Sulfoxide ReductasesMicrotubule-Associated ProteinsMSRB3 protein, humanNerve Tissue ProteinsProtein Serine-Threonine Kinases

Identifiers

PMID28098162
PMCPMC5253632

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