Evidence map›Paper›PMID 28098153›Full record

ArticleNature communications2017

MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice.

Keerthi Krishnan, Billy Y B Lau, Gabrielle Ewall, Z Josh Huang, Stephen D Shea

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Review
  3. Pubertal development is unaffected in femalemicroPublication biology · 2026
    Article
  4. Article
  5. Article
  6. Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Adolescent Parvalbumin Expression in the Left Orbitofrontal Cortex Shapes Sociability in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  19. Article
  20. Selective deletion ofbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Keerthi KrishnanCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.ORCID 0000-0002-0858-4624
Billy Y B LauCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Gabrielle EwallCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Z Josh HuangCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Stephen D SheaCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Cold Spring Harbor Laboratory · US

Funding

Cell-based genomic analysis of molecular pathology in Mouse Models of Rett SyndromeR01MH102616 · NIMH · COLD SPRING HARBOR LABORATORY · PI HUANG, Z JOSH · 2014 to 2018
$3.8M
Disrupted auditory cortical plasticity and behavior in a model of Rett syndromeR01MH106656 · NIMH · COLD SPRING HARBOR LABORATORY · PI SHEA, STEPHEN D · 2016 to 2020
$2.6M
NIMH NIH HHS R01 MH102616NIMH NIH HHS R01 MH106656
6 · The paper itself

Abstract

Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but how disruption of experience-dependent plasticity contributes to cognitive and behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour and associated auditory cortical plasticity are impaired in female Mecp2

Indexed as

Neuronal PlasticityAnimalsCerebral CortexFemalegamma-Aminobutyric AcidHumansLearningMaleMaternal BehaviorMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLMice, KnockoutRett Syndromegamma-Aminobutyric AcidMethyl-CpG-Binding Protein 2

Identifiers

PMID28098153
PMCPMC5253927
OpenAlexW2953266422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.