ArticleDeutsches Arzteblatt international2016
The Association of Hyponatremia, Risk of Confusional State, and Mortality.
Article in Deutsches Arzteblatt international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- AIDEBMC geriatrics · 2026Trial
- Association Between Hyponatremia and Mortality and Readmission in Multimorbid Older Adults-A Cohort Study.Journal of clinical medicine · 2025Article
- Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- The U-shaped relationship between serum osmolality and the risk of sepsis-associated delirium development: a retrospective study.BMC neurology · 2025Article
- Drug-Induced Cognitive Impairment.Drug safety · 2025Review
- Urban Heat and Burden of Hyponatremia.JAMA network open · 2024Article
- Delirium in Lower Limb Trauma: The Incidence and Risk Factors in a Prospective Observational Study.Indian journal of orthopaedics · 2024Article
- Incidence and Risk Factors for Hyponatremia in Postoperative Spinal Surgery Patients.Spine surgery and related research · 2024Article
- Comparative safety of adding serotonin and norepinephrine reuptake inhibitors (SNRIs) versus nonsteroidal anti-inflammatory drugs (NSAIDs) to short-acting opioids for non-malignant pain in nursing homes.Journal of the American Geriatrics Society · 2023Article
- Serum sodium improvement: change in Comprehensive Geriatric Assessment parameters in geriatric patients with hyponatremia.BMC geriatrics · 2023Article
- Prevalence, Risk Factors, and Mortality of Patients Presenting with Moderate and Severe Hyponatremia in Emergency Departments.Emergency medicine international · 2023Article
- The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units.Acute and critical care · 2022Article
- Article
- Increased Mortality in Elderly Patients Admitted with Hyponatremia: A Prospective Cohort Study.Journal of clinical medicine · 2021Article
- [Hyponatremia in older persons (part I)-keep diagnosis simple : How to detect tricks and avoid pitfalls].Zeitschrift fur Gerontologie und Geriatrie · 2020Article
- Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.Scientific reports · 2019Observational
- How to manage terminal dehydration.Der Anaesthesist · 2019Review
- Hyponatremia: Prevalence and characteristics in internal medicine patients in southeast of China.Medicine · 2018Article
- ["Terminal" dehydration, part 2 : Medical indications and therapeutic approach].Der Anaesthesist · 2018Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyponatremia and delirium are frequent problems in older hospitalized patients. Although confusional states are considered to be a possible complication of hyponatremia, there has been no systematic study to date of the precise prevalence of delirium among patients with hyponatremia and its effect on long-term outcomes.
methodsIn a 13-month period in 2009/2010, all patients with a serum sodium level less than or equal to 130 mmol/L (the hyponatremia group) in a cohort of hospitalized older patients were studied and compared to a normonatremic control group of patients who were matched for age, sex, and diagnosis group. The prevalence of delirium was determined by two-stage examination. Inhospital mortality, mortality six months after initial examination, and functional status were prospectively analyzed.
results179 patients were identified whose serum sodium level was less than or equal to 130 mmol/L (7.9% of all treated patients), of whom 141 were included in the hyponatremia group. The mean age of the participants was 83 (range, 63-102), and 84% were women. Patients with hyponatremia suffered more often from delirium (22.7% versus 8.5%; p = 0.002) and had a higher inhospital mortality (10.6% versus 2.1%; p = 0.005). The mortality six months after initial examination was 31.9% versus 22.7% (p = 0.080). 59.7% of patients in the hyponatremia group and 49% in the control group (p = 0.146) needed a higher level of chronic care after discharge than they had needed before the hospitalization.
conclusionHyponatremia in hospitalized older patients is associated with a higher likelihood of delirium and an elevated in-hospital mortality.
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