Evidence map›Paper›PMID 28097915›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2017

The relationship between angiotensin-converting enzyme (ACE) insertion (I) / deletion (D) polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese.

Ya-Feng Zhang, Hong Wang, Qiong Cheng, Ling Qin, Nelson Ls Tang, Ping-Chong Leung, Timothy Cy Kwok

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ya-Feng Zhang1 Department of Orthopaedics, The Affiliated Hospital to Nantong University, PR China.
Hong Wang1 Department of Orthopaedics, The Affiliated Hospital to Nantong University, PR China.
Qiong Cheng3 Jiangsu Provincial Key Laboratory of Neural Regeneration, Nantong University, PR China.
Ling Qin4 Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
Nelson Ls Tang5 Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
Ping-Chong Leung6 Jockey Club Center for Osteoporosis Care and Control, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
Timothy Cy Kwok2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China.
Chinese University of Hong Kong · CNNantong University · CNHong Kong Jockey Club · CN

Funding

Osteoporotic fractures in Chinese men: MrOs Hong KongR01AR049439 · NIAMS · CHINESE UNIVERSITY OF HONG KONG · PI LEUNG, PING CHUNG · 2003 to 2007
$2.0M
NIAMS NIH HHS R01 AR049439
6 · The paper itself

Abstract

objectiveIn this study, we set out to investigate the relationship between angiotensin-converting enzyme ( ACE) I/D polymorphism, serum ACE activity and bone mineral density (BMD) in older Chinese.

methodsA standardized, structured, face-to-face interview was performed to collect demographic information. BMD was measured using dual-energy X-ray absorptiometry (DXA). I/D genotypes of ACE were determined by polymerase chain reaction (PCR) amplification. Serum ACE activity was determined photometrically by a commercially available kinetic kit. Multiple linear regression analysis was used to examine the relationship between ACE I/D polymorphism, serum ACE activity and BMD.

resultsA total of 1567 males and 1760 females were selected for analyzing the relationship between ACE I/D polymorphism and BMD. There was no significant difference in spine BMD, total hip BMD and femur neck BMD among different ACE I/D genotypes both in males and females. A total of 1699 males and 1739 females were selected for analyzing the relationship between serum ACE activity and BMD. There was also no significant difference in spine BMD, total hip BMD and femur neck BMD among different serum ACE activity groups both in males and females.

conclusionThere was no relationship between ACE I/D polymorphism, serum ACE activity and BMD in older Chinese.

Indexed as

Polymorphism, GeneticAgedAsian PeopleBone DensityChinaFemaleGenotypeHumansINDEL MutationMalePeptidyl-Dipeptidase AACE protein, humanPeptidyl-Dipeptidase AAngiotensin-converting enzymebone mineral densityChineseI/D polymorphismserum ACE activity

Identifiers

PMID28097915
PMCPMC5843856
OpenAlexW2573215186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.