ReviewJournal of diabetes investigation2017
Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.
Review in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A global systematic overview of socioeconomic factors associated with antidiabetic medication adherence in individuals with type 2 diabetes.Journal of health, population, and nutrition · 2023Pooled it
- Novel Insights into Diabetic Kidney Disease.International journal of molecular sciences · 2024Review
- DNA Methylation Profiles ofBiomedicines · 2024Article
- Use of Transcriptome Sequencing to Analyze the Effects of Different Doses of an Astragalus-Rhubarb-Saffron Mixture in Mice with Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Article
- The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1.Kidney and dialysis · 2022Article
- Review
- Relations Between Urinary Albumin Excretion and a Dietary Intake of Fruits in Patients With Type 2 Diabetes.Journal of clinical medicine research · 2021Article
- Treatment of Diabetic Kidney Disease: Current and Future.Diabetes & metabolism journal · 2021Review
- A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan.Clinical and experimental nephrology · 2020Article
- Targeting Redox Imbalance as an Approach for Diabetic Kidney Disease.Biomedicines · 2020Review
- Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease.International journal of endocrinology · 2020Review
- Diabetic kidney disease: Its current trends and future therapeutic perspectives.Journal of diabetes investigation · 2019Article
- Renoprotective Effects of Additional SGLT2 inhibitor Therapy in Patients With Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3b-4: A Real World Report From A Japanese Specialized Diabetes Care Center.Journal of clinical medicine research · 2019Article
- Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle.Scientific reports · 2019Article
- Deletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney.American journal of physiology. Renal physiology · 2018Article
- Clinico-pathological features of kidney disease in diabetic cases.Clinical and experimental nephrology · 2018Review
- Article
- Renal biopsy-driven molecular target identification in glomerular disease.Pflugers Archiv : European journal of physiology · 2017Review
- Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.Journal of diabetes investigation · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic kidney disease (DKD) is a worldwide public health problem. The definition of DKD is under discussion. Although the term DKD was originally defined as 'kidney disease specific to diabetes,' DKD frequently means chronic kidney disease with diabetes mellitus and includes not only classical diabetic nephropathy, but also kidney dysfunction as a result of nephrosclerosis and other causes. Metabolic memory plays a crucial role in the progression of various complications of diabetes, including DKD. The mechanisms of metabolic memory in DKD are supposed to include advanced glycation end-products, deoxyribonucleic acid methylation, histone modifications and non-coding ribonucleic acid including micro ribonucleic acid. Regardless of the presence of diabetes mellitus, the final common pathway in chronic kidney disease is chronic kidney hypoxia, which influences epigenetic processes, including deoxyribonucleic acid methylation, histone modification, and conformational changes in micro ribonucleic acid and chromatin. Therefore, hypoxia and oxidative stress are appropriate targets of therapies against DKD. Prolyl hydroxylase domain inhibitor enhances the defensive mechanisms against hypoxia. Bardoxolone methyl protects against oxidative stress, and can even reverse impaired renal function; a phase 2 trial with considerable attention to heart complications is currently ongoing in Japan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.