Evidence map›Paper›PMID 28097523›Full record

ArticleJournal of cardiovascular translational research2017

Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model.

Victoria K Pepper, Elizabeth S Clark, Cameron A Best, Ekene A Onwuka, Tadahisa Sugiura, Eric D Heuer, Lilamarie E Moko, Shinka Miyamoto, Hideki Miyachi, Darren P Berman and 5 more

Open access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of cardiovascular translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  5. Article
  6. Systematic Review of Tissue-Engineered Vascular Grafts.Frontiers in bioengineering and biotechnology · 2021
    Review
  7. Article
  8. Article
  9. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2019
    Article
  10. Article
  11. Article
  12. Review
  13. Tissue Engineering-Bridging the Gap.Journal of cardiovascular translational research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Victoria K PepperTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Elizabeth S ClarkTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Cameron A BestTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Ekene A OnwukaTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Tadahisa SugiuraDivision of Cardiothoracic Transplant & Mechanical Circulatory Support, Texas Heart Institute at Baylor St. Luke's Medical Center, Houston, TX, USA.
Eric D HeuerTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Lilamarie E MokoTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Shinka MiyamotoTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Hideki MiyachiTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Darren P BermanThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Sharon L CheathamThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Joanne L ChisolmThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Toshiharu ShinokaTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA.
Christopher K BreuerTissue Engineering Program, Research Institute at Nationwide Children's Hospital, 700 Children's Drive, WB 4154, Columbus, OH, 43205, USA. christopher.breuer@nationwidechildrens.org.
John P CheathamThe Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Nationwide Children's Hospital · USSt. Luke's Hospital · USThe Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular GraftsR01HL098228 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE · 2010 to 2018
$3.6M
Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
Development of an Improved Vascular Graft for Use in Congenital Heart SurgeryR01HL128847 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE · 2016 to 2019
$2.8M
Computational Model Driven Design of Tissue Engineered Vascular GraftsR01HL128602 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2015 to 2018
$2.2M
Mouse Pathobiology: Models of Human DiseaseT32OD010429 · OD · OHIO STATE UNIVERSITY · PI NIEWIESK, STEFAN, OGLESBEE, MICHAEL J · 2012 to 2017
$1.3M
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL098228NHLBI NIH HHS R01 HL128602NHLBI NIH HHS R01 HL128847NIAID NIH HHS T32 AI106704NIH HHS T32 OD010429
6 · The paper itself

Abstract

Patients who undergo implantation of a tissue-engineered vascular graft (TEVG) for congenital cardiac anomalies are monitored with echocardiography, followed by magnetic resonance imaging or angiography when indicated. While these methods provide data regarding the lumen, minimal information regarding neotissue formation is obtained. Intravascular ultrasound (IVUS) has previously been used in a variety of conditions to evaluate the vessel wall. The purpose of this study was to evaluate the utility of IVUS for evaluation of TEVGs in our ovine model. Eight sheep underwent implantation of TEVGs either unseeded or seeded with bone marrow-derived mononuclear cells. Angiography, IVUS, and histology were directly compared. Endothelium, tunica media, and graft were identifiable on IVUS and histology at multiple time points. There was strong agreement between IVUS and angiography for evaluation of luminal diameter. IVUS offers a valuable tool to evaluate the changes within TEVGs, and clinical translation of this application is warranted.

Indexed as

BioprosthesisBlood Vessel ProsthesisBone Marrow TransplantationTissue ScaffoldsUltrasonography, InterventionalAnimalsBlood Vessel Prosthesis ImplantationCells, CulturedModels, AnimalPhlebographyPostoperative ComplicationsProsthesis DesignSheep, DomesticTime FactorsTissue EngineeringVena Cava, InferiorAngiographyIntravascular ultrasoundIVUSNeotissueStenosisTEVGTissue-engineered vascular graft

Identifiers

PMID28097523
PMCPMC5438289
OpenAlexW2576894960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.