ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017
Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Leiomyosarcoma of the abdomen and retroperitoneum; a systematic review.Frontiers in surgery · 2024Pooled it
- Pseudo-Pseudo Polyp: Spindle Cell Sarcoma at an Ileocolonic Anastomosis.ACG case reports journal · 2025Article
- Diagnostic and therapy of an early-stage primary leiomyosarcoma of the sigmoid colon: A case report.Clinical case reports · 2024Article
- Colorectal leiomyosarcoma withJournal of gastrointestinal oncology · 2022Article
- Primary leiomyosarcoma of the sigmoid colon: Case report and review of literature.Radiology case reports · 2022Article
- Spindle Cell Sarcoma (SCS); a case of primary leiomyosarcoma (LMS) of the sigmoid colon presented as intestinal obstruction.Journal of surgical case reports · 2021Article
- Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve.ACG case reports journal · 2021Article
- "Sarc" Attack: Rectal Bleeding in an Elderly Patient with Small Bowel Crohn's Disease.Digestive diseases and sciences · 2021Article
- Outcomes of surgically managed primary lung sarcomas: a National Cancer Database analysis.Journal of thoracic disease · 2021Article
- The prognostic factors of primary colorectal sarcoma and the clinical outcomes of negative lymph node dissection.Annals of translational medicine · 2021Article
- Surgical resection improves overall survival of patients with small bowel leiomyosarcoma.International journal of colorectal disease · 2020Article
- Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study.Annals of coloproctology · 2020Article
- Racial/Ethnic Disparities and Survival Characteristics in Non-Pancreatic Gastrointestinal Tract Neuroendocrine Tumors.Cancers · 2020Article
- Mesenteric Lymph Node Recurrence of a Primary Colorectal Leiomyosarcoma.Case reports in surgery · 2020Article
- Beyond adenocarcinoma: MRI of uncommon rectal neoplasms and mimickers.Abdominal radiology (New York) · 2019Review
- The opportunities and shortcomings of using big data and national databases for sarcoma research.Cancer · 2019Review
- Leiomyosarcoma of the Rectum as a Radiation-Induced Second Malignancy after Cervical Cancer Treatment: Case Report with Review of the Literature.Case reports in oncological medicine · 2019Article
- Assessment of the Accuracy of Disease Coding Among Patients Diagnosed With Sarcoma.JAMA oncology · 2018Article
- National cancer database analysis of outcomes in pediatric glioblastoma.Cancer medicine · 2018Article
- Primary leiomyosarcoma in the colon: A case report.Medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrimary colorectal sarcomas are a rare entity with anecdotally poor outcomes. We sought to inform surgeons, oncologists, and researchers of the characteristics and outcomes of these understudied and difficult-to-manage tumors.
methodsThe National Cancer Data Base (NCDB) was queried for patients with pathologically confirmed primary sarcoma of the colon or rectum (1998-2012). Gastrointestinal stromal tumors were excluded. Unadjusted overall survival was reported using the Kaplan-Meier method. Patients with colorectal adenocarcinoma were used as a comparison cohort.
resultsFour hundred thirty-three patients with primary colorectal sarcoma were identified (57.5% leiomyosarcoma subtype). Median age was 63 [inter-quartile range 52, 75] years with 23.1% between the ages of 18 and 50 and 48.7% female. Majority of sarcomas were located in the colon (70.7%). When compared to 696,902 patients with adenocarcinoma, sarcoma patients were younger, had larger tumors, were more likely node negative and rectal in location, and higher grade (all p < 0.001), while sex, race, and comorbidity score were similar (all p > 0.05). Overall survival was lower at 5 years in patients with sarcoma (43.8%) than adenocarcinoma (52.3%, p < 0.001).
conclusionPrimary colorectal sarcomas are rare and present at a younger age and higher grade than adenocarcinoma of the colon and rectum. Survival is significantly worse compared to adenocarcinoma patients.
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