Trial reportJCI insight2017
Protection against
2 registry-linked trialsOpen access · goldAbstract readClinical TrialComparative Study
In one paragraph
Trial report in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 149 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 1 pooled it
28.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses
Clinical Trial of PfSPZ Vaccine Administered by Direct Venous Inoculation: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults
Who cites it
149 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.
- Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review.BMC infectious diseases · 2021Pooled it
- Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection.Malaria journal · 2025Trial
- Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults.The Journal of clinical investigation · 2024Trial
- Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults.The American journal of tropical medicine and hygiene · 2023Trial
- Whole sporozoite immunization with Plasmodium falciparum strain NF135 in a randomized trial.BMC medicine · 2023Trial
- A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.Science translational medicine · 2022Trial
- Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children.BMC medicine · 2022Trial
- Trial
- Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial.The Lancet. Infectious diseases · 2022Trial
- Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.PLoS pathogens · 2022Trial
- Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial.Nature medicine · 2021Trial
- Trial
- Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial.Nature communications · 2021Trial
- Trial
- Trial
- Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Trial
- Controlled Human Malaria Infection of Healthy Adults With Lifelong Malaria Exposure to Assess Safety, Immunogenicity, and Efficacy of the Asexual Blood Stage Malaria Vaccine Candidate GMZ2.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 6 institutions in 1 country.
Judith E EpsteinNaval Medical Research Center (NMRC).
Kristopher M PaolinoWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Thomas L RichieSanaria Inc., Rockville, Maryland, USA.
Martha SedegahNaval Medical Research Center (NMRC).
Alexandra SingerNaval Medical Research Center (NMRC).
Adam J RubenSanaria Inc., Rockville, Maryland, USA.
Sumana ChakravartySanaria Inc., Rockville, Maryland, USA.
April StaffordWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Richard C RuckWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Abraham G EappenSanaria Inc., Rockville, Maryland, USA.
Tao LiSanaria Inc., Rockville, Maryland, USA.
Peter F BillingsleySanaria Inc., Rockville, Maryland, USA.
Anita ManojSanaria Inc., Rockville, Maryland, USA.
Joana C SilvaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kara MoserInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Robin NielsenWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Donna ToshWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Susan CicatelliWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Harini GaneshanNaval Medical Research Center (NMRC).
Jessica CaseStatistics Collaborative Inc., Washington, DC, USA.
Debbie PadillaSanaria Inc., Rockville, Maryland, USA.
Silas DavidsonWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Lindsey GarverWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Elizabeth SaverinoSanaria Inc., Rockville, Maryland, USA.
Tooba MurshedkarSanaria Inc., Rockville, Maryland, USA.
Anusha GunasekeraSanaria Inc., Rockville, Maryland, USA.
Patrick S TwomeyWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Sharina ReyesNaval Medical Research Center (NMRC).
James E MoonWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Eric R JamesSanaria Inc., Rockville, Maryland, USA.
Natasha KcSanaria Inc., Rockville, Maryland, USA.
Minglin LiSanaria Inc., Rockville, Maryland, USA.
Esteban AbotNaval Medical Research Center (NMRC).
Arnel BelmonteNaval Medical Research Center (NMRC).
Kevin HaunsWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Maria BelmonteNaval Medical Research Center (NMRC).
Jun HuangNaval Medical Research Center (NMRC).
Carlos VasquezNaval Medical Research Center (NMRC).
Shon RemichWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Mary CarringtonNaval Medical Research Center (NMRC).
Yonas AbebeSanaria Inc., Rockville, Maryland, USA.
Amy TillmanStatistics Collaborative Inc., Washington, DC, USA.
Bradley HickeyWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Jason RegulesWalter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Eileen VillasanteNaval Medical Research Center (NMRC).
B Kim Lee SimSanaria Inc., Rockville, Maryland, USA.
Stephen L HoffmanSanaria Inc., Rockville, Maryland, USA.
Sanaria · USWalter Reed Army Institute of Research · USNaval Medical Research Command · USStatistics Collaborative · USUniversity of Maryland, Baltimore · USProtein Potential (United States) · US
Funding
Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5MNIAID NIH HHS U19 AI110820
Abstract
PubMed holds no abstract for this paper.
Indexed as
Administration, IntravenousAdultFemaleHumansMalaria, FalciparumMalePlasmodium falciparumSporozoitesT-LymphocytesVaccines, AttenuatedWhole Genome SequencingVaccines, Attenuated
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02215707ClinicalTrials.gov
NCT02601716ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.