Evidence map›Paper›PMID 28097223›Full record

ArticleNeurology. Genetics2017

Mariet Allen, Sarah J Lincoln, Morgane Corda, Jens O Watzlawik, Minerva M Carrasquillo, Joseph S Reddy, Jeremy D Burgess, Thuy Nguyen, Kimberly Malphrus, Ronald C Petersen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The Abca7Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. The ABC's of Alzheimer risk gene ABCA7.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  7. Article
  8. PSEN2 and ABCA7 variants causing early-onset preclinical pathological changes in Alzheimer's disease: a case report and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  9. Article
  10. Clinical Deep Phenotyping ofNeurology. Genetics · 2022
    Article
  11. Article
  12. Role of ABCA7 in Human Health and in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  13. Review
  14. A novel variant c.3706C>T p.(Avg 1236Cys) in theIntractable & rare diseases research · 2020
    Article
  15. Article
  16. Is Alzheimer's Disease a Liver Disease of the Brain?Journal of Alzheimer's disease : JAD · 2020
    Review
  17. ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Review
  19. Article
  20. RareNeurology. Genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Mariet AllenForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Sarah J LincolnForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Morgane CordaForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Jens O WatzlawikForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Minerva M CarrasquilloForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Joseph S ReddyForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Jeremy D BurgessForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Thuy NguyenForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Kimberly MalphrusForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Ronald C PetersenForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Neill R Graff-RadfordForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Dennis W DicksonForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Nilüfer Ertekin-TanerForm the Department of Neuroscience (M.A., S.J.L., M.C., J.O.W., M.M.C., J.S.R., J.D.B., T.N., K.M., D.W.D., N.E.-T.), Department of Neurology (N.R.G.-R., N.E.-T.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (R.C.P.), Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · US

Funding

Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Gene discovery in PSP by transcriptome, neuropathology and sequence analysisR01NS080820 · NINDS · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2013 to 2017
$1.8M
NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG046139NINDS NIH HHS R01 NS080820
6 · The paper itself

Abstract

objectiveTo investigate and characterize putative "loss-of-function" (LOF) adenosine triphosphate-binding cassette, subfamily A member 7 (

methodsWe genotyped 6 previously reported

resultsAt least one of the investigated variants was identified in 45 participants with late-onset Alzheimer disease, 12 participants with other neuropathologies, and 11 elderly controls. Association analysis revealed a significantly higher burden of these variants in participants with AD (

conclusionsOur results suggest that LOF may not be a common mechanism for these

Identifiers

PMID28097223
PMCPMC5217615
OpenAlexW2568615724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.