ArticleAnnals of clinical and translational neurology2016
Distinct effects of obesity and puberty on risk and age at onset of pediatric MS.
Article in Annals of clinical and translational neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Phenotyping healthcare use before pediatric-onset multiple sclerosis, including by sex and age: A matched cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Prognostic factors in paediatric-onset multiple sclerosis: a narrative review.Journal of neurology · 2026Review
- Sex-Related Differences in Lifestyle Factors Affecting Multiple Sclerosis Susceptibility and Disease Progression.Brain sciences · 2025Review
- A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.Neurology · 2025Article
- Does Age at Menarche Differ Between Patients With Multiple Sclerosis and Healthy Controls?: An Updated Systematic Review and Meta-Analysis.Journal of family & reproductive health · 2025Review
- Review
- Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis.Journal of clinical medicine · 2024Article
- Juvenile multiple sclerosis: addressing epidemiology, diagnosis, therapeutic, and prognostic updates along with cognitive dysfunction and quality of life.Annals of medicine and surgery (2012) · 2023Review
- Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Socioeconomic, Clinical, and Laboratory Parameters Differentiating Pediatric Patients With MOG Antibody-Associated Disease and Multiple Sclerosis.Journal of child neurology · 2023Article
- Impact of endocrine dysregulation on disability and non-motor symptoms in pediatric onset multiple sclerosis.Frontiers in neurology · 2023Article
- Aging in multiple sclerosis: from childhood to old age, etiopathogenesis, and unmet needs: a narrative review.Frontiers in neurology · 2023Review
- Association of obesity with disease outcome in multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Body size perceptions & diet modification in youth with multiple sclerosis.Multiple sclerosis and related disorders · 2022Article
- Effect of puberty on the immune system: Relevance to multiple sclerosis.Frontiers in pediatrics · 2022Review
- Preventing Multiple Sclerosis: The Pediatric Perspective.Frontiers in neurology · 2022Review
- Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis.Paediatric drugs · 2021Review
- Obesity in Pediatric-Onset Multiple Sclerosis: A French Cohort Study.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Obesity and Multiple Sclerosis-A Multifaceted Association.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
24 authors at 18 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS.
methodsCase-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases. Sex-stratified associations between MS risk and age at symptom onset with both BMI and pubertal factors were estimated controlling for race and ethnicity.
resultsOnly 11% of girls and 15% of boys were prepubertal (Tanner stage I) at MS onset. 80% of girls had onset of MS after menarche. BMI percentiles were higher in MS cases versus controls (girls:
interpretationHigher BMI in early adolescence is a risk factor for MS in girls and boys. Earlier age at sexual maturity contributes to earlier age at MS onset, particularly in association with obesity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.