Evidence map›Paper›PMID 28097155›Full record

ArticleJournal of immunology research2016

Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis.

Lina Mattson, Antonio Lentini, Danuta R Gawel, Tejaswi V S Badam, Mikael Benson, Torbjorn Ledin, Colm E Nestor, Mika Gustafsson, Jordi Serra-Musach, Janne Bjorkander and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [The research progress of mechanism of allergen immunotherapy in allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  5. Article
  6. Mechanisms of Allergen Immunotherapy in Allergic Rhinitis.Current allergy and asthma reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Lina MattsonThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Antonio LentiniThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Danuta R GawelThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Tejaswi V S BadamThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden; Bioinformatics, Department of Physics, Chemistry and Biology, Linkoping University, SE-581 83 Linkoping, Sweden.
Mikael BensonThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Torbjorn LedinDivision of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden; Department of Otorhinolaryngology in Linkoping, Anaesthetics, Operations and Specialty Surgery Center, Region Ostergotland, Sweden.
Colm E NestorThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Mika GustafssonThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden; Bioinformatics, Department of Physics, Chemistry and Biology, Linkoping University, SE-581 83 Linkoping, Sweden.
Jordi Serra-MusachThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.
Janne BjorkanderFuturum-Academy for Health and Care, County Council of Jonkoping, Jonkoping, Sweden.
Zou XiangDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Huan ZhangThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden.ORCID 0000-0001-9339-7999
Linköping University · SEHong Kong Polytechnic University · HKRegion Jönköpings län · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4

Indexed as

AdultBetulaCells, CulturedFemaleHumansImmunotherapyInterferon-alphaInterferon-betaInterferon-gammaLeukocytes, MononuclearMiddle AgedPollenPrincipal Component AnalysisRhinitis, Allergic, SeasonalSignal TransductionSTAT1 Transcription FactorInterferon-alphaInterferon-betaInterferon-gammaSTAT1 protein, humanSTAT1 Transcription FactorSTAT2 protein, humanSTAT2 Transcription Factor

Identifiers

PMID28097155
PMCPMC5209614
OpenAlexW2564828154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.