ArticleNeural plasticity2016
Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Postnatal environment affects auditory development and sensorimotor gating in a rat model for autism spectrum disorder.Frontiers in neuroscience · 2025Article
- Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro.Development (Cambridge, England) · 2023Article
- Profiling mouse cochlear cell maturation using 10× Genomics single-cell transcriptomics.Frontiers in cellular neuroscience · 2022Article
- Long-Term Release of Dexamethasone With a Polycaprolactone-Coated Electrode Alleviates Fibrosis in Cochlear Implantation.Frontiers in cell and developmental biology · 2021Article
- Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons.Neural plasticity · 2021Article
- Functional Postnatal Maturation of the Medial Olivocochlear Efferent-Outer Hair Cell Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats.Journal of visualized experiments : JoVE · 2018Article
- Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice.Neural plasticity · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear. The electromotility of OHCs driven by prestin is responsible for the cochlear amplification which is required for normal hearing in adult animals. Postnatal expression of prestin and activity of OHCs may contribute to the maturation of hearing in rodents. However, the temporal and spatial expression of prestin in cochlea during the development is not well characterized. In the present study, we examined the expression and function of prestin from the OHCs in apical, middle, and basal turns of the cochleae of postnatal rats. Prestin first appeared at postnatal day 6 (P6) for basal turn, P7 in middle turn, and P9 for apical turn of cochlea. The expression level increased progressively over the next few days and by P14 reached the mature level for all three segments. By comparison with the time course of the development of auditory brainstem response for different frequencies, our data reveal that prestin expression synchronized with the hearing development. The present study suggests that the onset time of hearing may require the expression of prestin and is determined by the mature function of OHCs.
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