ArticleIranian journal of basic medical sciences2016
The effect of aminoguanidine on sperm motility and mitochondrial membrane potential in varicocelized rats.
Article in Iranian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Effect of adding different concentrations of L-arginine to Tris-yolk extender on the quality of sub-fertile ejaculates in buffalo.Tropical animal health and production · 2021Article
- Regulation of boar sperm functionality by the nitric oxide synthase/nitric oxide system.Journal of assisted reproduction and genetics · 2019Article
- Aminoguanidine Protects Boar Spermatozoa against the Deleterious Effects of Oxidative Stress.Pharmaceutics · 2018Article
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Authors and funding
8 authors at 7 institutions in 2 countries.
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Abstract
objectivesIncreased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicocelized rats. MATERIALS AND
methodsTwenty fore male Wister rats were divided into control, sham, varicocele, and treatment groups. Varicocele and treatment groups underwent partial ligation of left renal vein. Rats in the sham group underwent the same procedures as the varicocele group with the exception of vein ligation. 10 weeks after varicocele induction, sperm parameters were evaluated in all groups. The treatment group received 50 mg/kg AG injection daily for 10 weeks after which they were sacrificed prior to assessment of the parameters. Sperm viability and MMP were assessed by flow cytometry using propidium iodide (PI) and rhodamine 123 (Rh123), respectively.
resultsThe results of this study show a decrease in sperm viability, motility and MMP in the varicocele group compared with the other groups. After AG injection, we observed that all the parameters were significantly enhanced in the treatment group compared with the other groups. Rh123 staining revealed a positive relation between MMP and sperm motility, whereas PI staining showed a positive relation between sperm motility and viability.
conclusionThe findings of our study show that AG improves sperm motility and MMP, and thus, might be useful in the management of varicocele-related infertility.
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