Evidence map›Paper›PMID 28096806›Full record

ArticleFrontiers in genetics2016

A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal.

Nicole A R Walter, DeAunne L Denmark, Laura B Kozell, Kari J Buck

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicole A R WalterResearch and Development, Portland Veterans Affairs Medical Center, PortlandOR, USA; Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Science University, PortlandOR, USA.
DeAunne L DenmarkResearch and Development, Portland Veterans Affairs Medical Center, PortlandOR, USA; Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Science University, PortlandOR, USA.
Laura B KozellResearch and Development, Portland Veterans Affairs Medical Center, PortlandOR, USA; Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Science University, PortlandOR, USA.
Kari J BuckResearch and Development, Portland Veterans Affairs Medical Center, PortlandOR, USA; Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Science University, PortlandOR, USA.
Oregon Health & Science University · USPortland VA Medical Center · US

Funding

GENETIC VULNERABILITY TO DRUGS OF ABUSER01DA005228 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BUCK, KARI J · 1989 to 2015
$4.6M
The Role of Mpdz in Ethanol Withdrawal and Genetically Correlated BehaviorsR01AA011114 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BUCK, KARI J · 2000 to 2020
$4.3M
Mouse Genetic Models for Alcohol ResearchR24AA020245 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2011 to 2020
$2.3M
Genetic Vulnerability to Alcohol Withdrawal and Genetically Correlated BehaviorsI01BX000222 · VA · PORTLAND VA MEDICAL CENTER · PI BUCK, KARI J · 2009 to 2018
–
BLRD VA I01 BX000222NIAAA NIH HHS R01 AA011114NIAAA NIH HHS R24 AA020245NIDA NIH HHS R01 DA005228
6 · The paper itself

Abstract

Genetic factors significantly affect vulnerability to alcohol dependence (alcoholism). We previously identified quantitative trait loci on distal mouse chromosome 1 with large effects on predisposition to alcohol physiological dependence and associated withdrawal following both chronic and acute alcohol exposure in mice (

Indexed as

alcoholismcongenicmouse modelsN-acetylcysteineoxidative stresswithdrawal

Identifiers

PMID28096806
PMCPMC5206817
OpenAlexW2561321221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.