ReviewFrontiers in psychiatry2016
Neuroendocrinology of a Male-Specific Pattern for Depression Linked to Alcohol Use Disorder and Suicidal Behavior.
Review in Frontiers in psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts.Frontiers in public health · 2021Pooled it
- Men's Suicidal thoughts and behaviors and conformity to masculine norms: A person-centered, latent profile approach.Heliyon · 2024Article
- Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects.Neuroscience applied · 2024Article
- Article
- The Association of Gender Role Attitudes and Risky Drinking: Changes in the Relationship between Masculinity and Drinking in Korean Young Men.International journal of environmental research and public health · 2022Article
- Gender Differences in Attachment Anxiety and Avoidance and Their Association with Psychotherapy Use-Examining Students from a German University.Behavioral sciences (Basel, Switzerland) · 2022Article
- Perspective: Chicken Models for Studying the Ontogenetic Origin of Neuropsychiatric Disorders.Biomedicines · 2022Article
- Mechanisms affecting brain remodeling in depression: do all roads lead to impaired fibrinolysis?Molecular psychiatry · 2022Review
- Men's Psychotherapy Use, Male Role Norms, and Male-Typical Depression Symptoms: Examining 716 Men and Women Experiencing Psychological Distress.Behavioral sciences (Basel, Switzerland) · 2021Article
- Treatment-Resistant Depression Revisited: A Glimmer of Hope.Journal of personalized medicine · 2021Review
- Article
- Gender Differences in Developing Biomarker-Based Major Depressive Disorder Diagnostics.International journal of molecular sciences · 2020Article
- Demographic and Clinical Differences Between Bipolar Disorder Patients With and Without Alcohol Use Disorders.Frontiers in psychiatry · 2020Article
- Do dehydroepiandrosterone, progesterone, and testosterone influence women's depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women.Psychoneuroendocrinology · 2019Article
- Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior.Molecular neurobiology · 2019Article
- Mental health of the male adolescent and young man: the Copenhagen statement.World journal of pediatrics : WJP · 2018Review
- Commentary: Physical Functional Capacity and C-Reactive Protein in Schizophrenia.Frontiers in psychiatry · 2018Article
- No Difference in Mood and Quality of Life in DHEA-S Deficient Adults with Addison's Disease vs. Type 2 Diabetes Patients with Normal DHEA-S Levels: Implications for Management of These Conditions.Frontiers in psychology · 2017Article
- Bipolar Spectrum Disorders in Male Youth: The Interplay between Symptom Severity, Inflammation, Steroid Secretion, and Body Composition.Frontiers in psychiatry · 2017Review
- Emotions and Steroid Secretion in Aging Men: A Multi-Study Report.Frontiers in psychology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies show low rates of diagnosed depression in men compared to women. At the same time, high rates of alcohol use disorders (AUDs) and completed suicide are found among men. These data suggest that a male-specific pattern for depression may exist that is linked to AUDs and suicidal behavior. To date, no underlying neuroendocrine model for this specific pattern of male depression has been suggested. In this paper, we integrate findings related to this specific pattern of depression with underlying steroid secretion patterns, polymorphisms, and methylation profiles of key genes in order to detail an original neuroendocrine model of male-specific depression. Low circulating levels of sex steroids seem to increase the vulnerability for male depression, while concomitant high levels of glucocorticoids further intensify this vulnerability. Interactions of hypothalamus-pituitary-gonadal (HPG) and hypothalamus-pituitary-adrenocortical (HPA) axis-related hormones seem to be highly relevant for a male-specific pattern of depression linked to AUDs and suicidal behavior. Moreover, genetic variants and the epigenetic profiles of the androgen receptor gene, well-known depression related genes, and HPA axis-related genes were shown to further interact with men's steroid secretion and thus may further contribute to the proposed male-specific pattern for depression. This mini-review points out the multilevel interactions between the HPG and HPA axis for a male-specific pattern of depression linked to AUDs and suicidal behavior. An integration of multilevel interactions within the three-hit concept of vulnerability and resilience concludes the review.
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