ArticleNeuropsychiatric disease and treatment2017
Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Functional MRI-Specific Alterations in Salience Network in Mild Cognitive Impairment: An ALE Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation.Frontiers in aging neuroscience · 2021Pooled it
- Apathy in Mild Behavioural Impairment: Associations with Cortical Thickness and Grey Matter Volume.medRxiv : the preprint server for health sciences · 2026Article
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Predicting apathy using connectome-based models derived from static and dynamic brain connectivity.Social cognitive and affective neuroscience · 2026Article
- Multimodal Neuroimaging Mechanisms of Apathy in Alzheimer's Disease: A Narrative Review of Structural, Functional, and Molecular Evidence.International journal of general medicine · 2026Review
- Fronto-motor circuits linked to effort-based decision-making and apathy in healthy subjects.Communications biology · 2025Article
- Salience network segregation mediates the effect of tau pathology on mild behavioral impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Salience Network Segregation Mediates the Effect of Tau Pathology on Mild Behavioral Impairment.medRxiv : the preprint server for health sciences · 2024Article
- Functional connectivity and mild behavioral impairment in dementia-free elderly.Alzheimer's & dementia (New York, N. Y.) · 2023Article
- The neural correlates of apathy in the context of aging and brain disorders: a meta-analysis of neuroimaging studies.Frontiers in aging neuroscience · 2023Review
- Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms.Frontiers in aging neuroscience · 2023Article
- Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia.Brain : a journal of neurology · 2022Review
- Hypothalamic Functional Connectivity and Apathy in People with Alzheimer's Disease and Cognitively Normal Healthy Controls.Journal of Alzheimer's disease : JAD · 2022Article
- Diagnostic criteria for apathy in neurocognitive disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Multimodal brain imaging connectivity analyses of emotional and motivational deficits in depression among women.Journal of psychiatry & neuroscience : JPN · 2021Article
- Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several prior works reported that apathy is associated with conversion to Alzheimer's disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects.
methodsFifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects.
resultsWe observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group.
conclusionOur findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI.
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