Evidence map›Paper›PMID 28096667›Full record

ArticleInternational journal of nanomedicine2017

Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy.

Rui-Meng Yang, Chao-Ping Fu, Jin-Zhi Fang, Xiang-Dong Xu, Xin-Hua Wei, Wen-Jie Tang, Xin-Qing Jiang, Li-Ming Zhang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
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  5. Review
  6. Hybrid FeWOInternational journal of nanomedicine · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
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  14. Article
  15. Prussian blue nanosphere-embeddedActa pharmaceutica Sinica. B · 2019
    Article
  16. Review
  17. Review
  18. Article
  19. Injectable hydrogel encapsulating CuJournal of nanobiotechnology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui-Meng YangDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Chao-Ping FuSchool of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China.
Jin-Zhi FangDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Xiang-Dong XuDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Xin-Hua WeiDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Wen-Jie TangDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Xin-Qing JiangDepartment of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University.
Li-Ming ZhangSchool of Materials Science and Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorContrast MediaDextransFemaleHumansHyaluronan ReceptorsHyaluronic AcidMagnetic Resonance ImagingMagnetite NanoparticlesMice, Inbred BALB CTheranostic NanomedicineXenograft Model Antitumor AssaysCD44 protein, humanContrast MediaDextransferumoxidesHyaluronan ReceptorsHyaluronic AcidMagnetite Nanoparticlesbioactive glycosaminoglycanbreast carcinomacellular uptakeiron oxide nanoparticlesmagnetic resonance imagingsurface functionalization

Identifiers

PMID28096667
PMCPMC5214799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.