Evidence map›Paper›PMID 28096659›Full record

Trial reportDrug design, development and therapy2017

Effects of multiple-dose ponesimod, a selective S1P

Stipo Jurcevic, Pierre-Eric Juif, Colleen Hamid, Roseanna Greenlaw, Daniele D'Ambrosio, Jasper Dingemanse

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Modeling the Effect of the Selective S1PPharmaceutical research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stipo JurcevicDepartment of Biomedical Sciences, University of Westminster, London, UK.
Pierre-Eric JuifDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Colleen HamidDivision of Transplantation Immunology & Mucosal Biology, King's College London, London, UK.
Roseanna GreenlawDivision of Transplantation Immunology & Mucosal Biology, King's College London, London, UK.
Daniele D'AmbrosioDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Jasper DingemanseDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effects of ponesimod, a selective S1P

Indexed as

Administration, OralB-LymphocytesDose-Response Relationship, DrugFlow CytometryHealthy VolunteersHumansLymphocyte SubsetsReceptors, LysosphingolipidThiazolesT-LymphocytesponesimodReceptors, LysosphingolipidThiazolesCD45RA/CCR7lymphocyte subsetsmultiple doseponesimodS1P1 receptor

Identifiers

PMID28096659
PMCPMC5207338

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.