Evidence map›Paper›PMID 28096657›Full record

SynthesisDrug design, development and therapy2017

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis.

Shao-Jun Huang, Xian-Hua Wang, Zhi-Dong Liu, Wen-Li Cao, Yi Han, Ai-Guo Ma, Shao-Fa Xu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 11 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 11 syntheses or guidelines pooled it, 170 citations in OpenAlex.

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  13. Efficacy of vitamin DThe lancet. HIV · 2020
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  17. Vitamin D in pulmonary disease.Breathe (Sheffield, England) · 2026
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shao-Jun HuangDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Xian-Hua WangDepartment of Nutrition and Food Hygiene, Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, People's Republic of China.
Zhi-Dong LiuDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Wen-Li CaoDepartment of Pulmonary Medicine, Beijing Geriatric Hospital, Beijing, People's Republic of China.
Yi HanDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Ai-Guo MaDepartment of Nutrition and Food Hygiene, Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, People's Republic of China.
Shao-Fa XuDepartment of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, People's Republic of China.
Beijing Chest Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimTo conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB).

methodsPubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3.

resultsA significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population. A significantly lower vitamin D level was found in human immunodeficiency virus-TB-coinfected African patients receiving antiretroviral treatment who developed TB-associated immune reconstitution inflammatory syndrome vs those who did not develop TB-associated immune reconstitution inflammatory syndrome. VDD was associated with an increased risk of developing active TB in those subjects with latent TB infection and with an increased risk of tuberculin skin test conversion/TB infection conversion, and the trend toward a lower vitamin D level in active TB patients vs latent TB infection subjects did not reach statistical significance, indicating that VDD was more likely a risk factor than a consequence of TB. This concept was further strengthened by our result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment.

conclusionOur analyses revealed an association between vitamin D and TB. VDD is more likely a risk factor for TB than its consequence. More studies are needed to determine whether vitamin D supplementation is beneficial to TB prevention and treatment.

Indexed as

Anti-Retroviral AgentsAntitubercular AgentsHIV InfectionsHumansRisk FactorsTuberculosisVitamin D DeficiencyAnti-Retroviral AgentsAntitubercular Agents25-hydroxyvitamin Dmeta-analysistuberculosisvitamin Dvitamin D deficiency

Identifiers

PMID28096657
PMCPMC5207333
OpenAlexW2560969426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.