Evidence map›Paper›PMID 28096471›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Resolving the Brainstem Contributions to Attentional Analgesia.

Jonathan C W Brooks, Wendy-Elizabeth Davies, Anthony E Pickering

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 70 citations in OpenAlex.

  1. Trial
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  10. Automatic Geometry-based Estimation of the Locus Coeruleus Region on TbioRxiv : the preprint server for biology · 2024
    Article
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  12. Review
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  17. Brainstem Diffusion Tensor Tractography and Clinical Applications in Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  18. Article
  19. Article
  20. Brainstem Mechanisms of Pain Modulation: A within-Subjects 7T fMRI Study of Placebo Analgesic and Nocebo Hyperalgesic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jonathan C W BrooksClinical Research Imaging Centre and.
Wendy-Elizabeth DaviesSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom, and.
Anthony E PickeringSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom, and Tony.Pickering@Bristol.ac.uk.ORCID 0000-0003-0345-0456
University Clinical Centre · PLUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of Bristol · GB

Funding

Medical Research Council G0700238Medical Research Council MR/N026969/1Wellcome TrustWellcome Trust 088373
6 · The paper itself

Abstract

Previous human imaging studies manipulating attention or expectancy have identified the periaqueductal gray (PAG) as a key brainstem structure implicated in endogenous analgesia. However, animal studies indicate that PAG analgesia is mediated largely via caudal brainstem structures, such as the rostral ventromedial medulla (RVM) and locus coeruleus (LC). To identify their involvement in endogenous analgesia, we used brainstem optimized, whole-brain imaging to record responses to concurrent thermal stimulation (left forearm) and visual attention tasks of titrated difficulty in 20 healthy subjects. The PAG, LC, and RVM were anatomically discriminated using a probabilistic atlas. Pain ratings disclosed the anticipated analgesic interaction between task difficulty and pain intensity (

Indexed as

AnalgesiaAdolescentAdultAnalysis of VarianceAttentionBody TemperatureBrain MappingBrain StemFemaleHumansImage Processing, Computer-AssistedLocus CoeruleusMagnetic Resonance ImagingMaleMedulla OblongataMiddle Agedattentionbrainstemendogenous analgesialocus coeruleusperiaqueductal grayrostral ventromedial medulla

Identifiers

PMID28096471
PMCPMC5354342
OpenAlexW2561584446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.