ArticleProceedings of the National Academy of Sciences of the United States of America2017
RFamide-related peptide-3 (RFRP-3) suppresses sexual maturation in a eusocial mammal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Basic biology is not just "for the birds": how avian studies have informed us about vertebrate reproduction.F&S reports · 2025Article
- Huatan Tongmai Yin regulates RFRP-3 to intervene in the "microbe-gut-HPO axis" to treat PCOS-IR rats.American journal of translational research · 2025Article
- The Role of RFRP Neurons in the Allostatic Control of Reproductive Function.International journal of molecular sciences · 2023Review
- Effects of Group Size on Behavior, Reproduction, and mRNA Expression in Brains of Brandt's Voles.Brain sciences · 2023Article
- Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS.Frontiers in endocrinology · 2023Article
- Socially Induced Infertility in Naked and Damaraland Mole-Rats: A Tale of Two Mechanisms of Social Suppression.Animals : an open access journal from MDPI · 2022Review
- For the physiology of cooperative breeding, it's time to move beyond stress: A Comment on: 'Stress in an underground empire' (2022) by Medger.Biology letters · 2022Article
- Social stress is unlikely to play a major role in reproductive suppression of female subordinate naked mole-rats and Damaraland mole-rats.Biology letters · 2022Article
- Article
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- An Inhibitory Circuit From Brainstem to GnRH Neurons in Male Mice: A New Role for the RFRP Receptor.Endocrinology · 2021Article
- RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction.Molecular biology reports · 2021Review
- Adult Neural Plasticity in Naked Mole-Rats: Implications of Fossoriality, Longevity and Sociality on the Brain's Capacity for Change.Advances in experimental medicine and biology · 2021Article
- Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.The European journal of neuroscience · 2020Article
- Effect of GABA-T on Reproductive Function in Female Rats.Animals : an open access journal from MDPI · 2020Article
- Changes in prolactin, cortisol and testosterone concentrations during queen succession in a colony of naked mole-rats (Heterocephalus glaber): a case study.Die Naturwissenschaften · 2019Article
- Effects of Social Information on the Release and Expression of Gonadotropin-Inhibitory Hormone in Birds.Frontiers in endocrinology · 2019Review
- The Gonadotropin-Inhibitory Hormone: What We Know and What We Still Have to Learn From Fish.Frontiers in endocrinology · 2019Review
- The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction.Iranian journal of basic medical sciences · 2018Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony. Because of its inhibitory action on the reproductive axis in other vertebrates, we investigated the role of RFRP-3 in social reproductive suppression in NMRs. We report that RFRP-3 immunofluorescence expression patterns and RFRP-3/GnRH cross-talk are largely conserved in the NMR brain, with the exception of the unique presence of RFRP-3 cell bodies in the arcuate nucleus (Arc). Immunofluorescence comparisons revealed that central expression of RFRP-3 is altered by reproductive status, with RFRP-3 immunoreactivity enhanced in the paraventricular nucleus, dorsomedial nucleus, and Arc of reproductively quiescent NMRs. We further observed that exogenous RFRP-3 suppresses gonadal steroidogenesis and mating behavior in NMRs given the opportunity to undergo puberty. Together, our findings establish a role for RFRP-3 in preserving reproductive immaturity, and challenge the view that stimulatory peptides are the ultimate gatekeepers of puberty.
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