ArticleProceedings of the National Academy of Sciences of the United States of America2017
Network-based integration of systems genetics data reveals pathways associated with lignocellulosic biomass accumulation and processing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- A haplotype-resolved reference genome for Eucalyptus grandis.G3 (Bethesda, Md.) · 2025Article
- ViLoN-a multi-layer network approach to data integration demonstrated for patient stratification.Nucleic acids research · 2023Article
- Haplogenome assembly reveals structural variation in Eucalyptus interspecific hybrids.GigaScience · 2022Article
- High-density genetic linkage mapping reveals low stability of QTLs across environments for economic traits inFrontiers in plant science · 2022Article
- qtlXplorer: an online systems genetics browser in the Eucalyptus Genome Integrative Explorer (EucGenIE).BMC bioinformatics · 2021Article
- Quantitative genetic analysis of wood property traits in biparental population ofJournal of genetics · 2021Article
- A systems genetics approach reveals environment-dependent associations between SNPs, protein coexpression, and drought-related traits in maize.Genome research · 2020Article
- Metabolic changes in the developing sugarcane culm associated with high yield and early high sugar content.Plant direct · 2020Article
- Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections.Experimental and therapeutic medicine · 2019Article
- Time-specific and pleiotropic quantitative trait loci coordinately modulate stem growth in Populus.Plant biotechnology journal · 2019Article
- Data Integration in Poplar: 'Omics Layers and Integration Strategies.Frontiers in genetics · 2019Review
- Xylan in the Middle: Understanding Xylan Biosynthesis and Its Metabolic Dependencies Toward Improving Wood Fiber for Industrial Processing.Frontiers in plant science · 2019Review
- The Road to Resistance in Forest Trees.Frontiers in plant science · 2019Review
- Systems and Synthetic Biology of Forest Trees: A Bioengineering Paradigm for Woody Biomass Feedstocks.Frontiers in plant science · 2019Review
- Finding New Cell Wall Regulatory Genes inFrontiers in plant science · 2019Article
- A Computational Model for Inferring QTL Control Networks Underlying Developmental Covariation.Frontiers in plant science · 2019Article
- Co-expression network of transcription factors reveal ethylene-responsive element-binding factor as key regulator of wood phenotype in3 Biotech · 2018Article
- Decoding Common Features of Neurodegenerative Disorders: From Differentially Expressed Genes to Pathways.Current genomics · 2018Article
- Six degrees of depolarization: Comment on "Network science of biological systems at different scales: A review" by Marko Gosak et al.Physics of life reviews · 2018Article
- Hardwood Tree Genomics: Unlocking Woody Plant Biology.Frontiers in plant science · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a consequence of their remarkable adaptability, fast growth, and superior wood properties, eucalypt tree plantations have emerged as key renewable feedstocks (over 20 million ha globally) for the production of pulp, paper, bioenergy, and other lignocellulosic products. However, most biomass properties such as growth, wood density, and wood chemistry are complex traits that are hard to improve in long-lived perennials. Systems genetics, a process of harnessing multiple levels of component trait information (e.g., transcript, protein, and metabolite variation) in populations that vary in complex traits, has proven effective for dissecting the genetics and biology of such traits. We have applied a network-based data integration (NBDI) method for a systems-level analysis of genes, processes and pathways underlying biomass and bioenergy-related traits using a segregating Eucalyptus hybrid population. We show that the integrative approach can link biologically meaningful sets of genes to complex traits and at the same time reveal the molecular basis of trait variation. Gene sets identified for related woody biomass traits were found to share regulatory loci, cluster in network neighborhoods, and exhibit enrichment for molecular functions such as xylan metabolism and cell wall development. These findings offer a framework for identifying the molecular underpinnings of complex biomass and bioprocessing-related traits. A more thorough understanding of the molecular basis of plant biomass traits should provide additional opportunities for the establishment of a sustainable bio-based economy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.