ArticleProceedings of the National Academy of Sciences of the United States of America2017
Measurement of cortical elasticity in Drosophila melanogaster embryos using ferrofluids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Developmentally programmed changes in cytoplasmic mechanics revealed by active microrheology inbioRxiv : the preprint server for biology · 2026Article
- Drosophila embryo cellularization is tuned by the viscoelastic properties of membrane-cortex linkers.Biophysical journal · 2026Article
- Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord.Developmental cell · 2025Article
- Application and measurement of tissue-scale tension in avian epithelia in vivo to study multiscale mechanics and inter-germ layer coupling.Development (Cambridge, England) · 2025Article
- Measuring molecular forces inside living cells using magnetic tweezers.Biophysical reviews · 2025Review
- Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.Nature communications · 2025Article
- Measuring and manipulating mechanical forces during development.Nature cell biology · 2025Review
- Structural response of microtubule and actin cytoskeletons to direct intracellular load.The Journal of cell biology · 2025Article
- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster.Developmental cell · 2025Article
- Article
- Computing whole embryo strain maps during gastrulation.Biophysical journal · 2024Article
- Viscous shear is a key force in Drosophila ventral furrow morphogenesis.Development (Cambridge, England) · 2024Article
- Deformable microlaser force sensing.Light, science & applications · 2024Article
- The Geometric Basis of Epithelial Convergent Extension.bioRxiv : the preprint server for biology · 2024Article
- Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development.Results and problems in cell differentiation · 2024Review
- Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in earlyProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Actomyosin pulsing rescues embryonic tissue folding from disruption by myosin fluctuations.Research square · 2023Article
- Tissue Morphogenesis Through Dynamic Cell and Matrix Interactions.Annual review of cell and developmental biology · 2023Review
- A comprehensive model ofeLife · 2023Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Many models of morphogenesis are forced to assume specific mechanical properties of cells, because the actual mechanical properties of living tissues are largely unknown. Here, we measure the rheology of epithelial cells in the cellularizing Drosophila embryo by injecting magnetic particles and studying their response to external actuation. We establish that, on timescales relevant to epithelial morphogenesis, the cytoplasm is predominantly viscous, whereas the cellular cortex is elastic. The timescale of elastic stress relaxation has a lower bound of 4 min, which is comparable to the time required for internalization of the ventral furrow during gastrulation. The cytoplasm was measured to be ∼10
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