Evidence map›Paper›PMID 28096357›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Prion replication without host adaptation during interspecies transmissions.

Jifeng Bian, Vadim Khaychuk, Rachel C Angers, Natalia Fernández-Borges, Enric Vidal, Crystal Meyerett-Reid, Sehun Kim, Carla L Calvi, Jason C Bartz, Edward A Hoover and 4 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 82 citations in OpenAlex.

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  7. Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Prion diseases: Lessons from historical outbreaks and potential emerging ones.Protein science : a publication of the Protein Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Jifeng BianPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Vadim KhaychukPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Rachel C AngersDepartment of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40506.
Natalia Fernández-BorgesCenter for Cooperative Research in Biosciences (CIC bioGUNE), Parque Tecnológico de Bizkaia, Derio 48160, Bizkaia, Spain.
Enric VidalCentre for Research into Animal Health (CReSA), Institute of Agri-Food Research and Technology (IRTA), Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Catalonia, Spain.ORCID 0000-0002-4965-3286
Crystal Meyerett-ReidPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Sehun KimPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Carla L CalviPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Jason C BartzDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178.
Edward A HooverPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525.
Umberto AgrimiDepartment of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, 00161 Rome, Italy.
Jürgen A RichtDiagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506.
Joaquín CastillaCenter for Cooperative Research in Biosciences (CIC bioGUNE), Parque Tecnológico de Bizkaia, Derio 48160, Bizkaia, Spain.
Glenn C TellingPrion Research Center (PRC), Colorado State University, Fort Collins, CO 80525; glenn.telling@colostate.edu.
Colorado State University · USCIC bioGUNE · ESCreighton University · USIkerbasque · ESIstituto Superiore di Sanità · ITKansas State University · USUniversitat Autònoma de Barcelona · ESUniversity of Kentucky · US

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EDWARD Arthur HOOVER · 2008 to 2026
$36.1M
TRANSGENETIC STUDIES OF PRION DISEASE IN CERVIDSR01NS040334 · NINDS · UNIVERSITY OF KENTUCKY · PI TELLING, GLENN C · 2000 to 2014
$5.6M
Transmission and Pathogenesis of Chronic Wasting Disease (CWD)R01NS061902 · NINDS · COLORADO STATE UNIVERSITY · PI MATHIASON, CANDACE K. · 2009 to 2022
$5.3M
Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
NIAID NIH HHS P01 AI077774NIGMS NIH HHS P30 GM103509NINDS NIH HHS R01 NS040334NINDS NIH HHS R01 NS061902
6 · The paper itself

Abstract

Adaptation of prions to new species is thought to reflect the capacity of the host-encoded cellular form of the prion protein (PrP

Indexed as

AnimalsDeerGuanidineHorsesHost SpecificityMiceMice, Inbred C57BLPrion DiseasesPrionsProtein ConformationProtein DenaturationPrPC ProteinsRabbitsSheepSpecies SpecificityStructure-Activity RelationshipGuanidinePrionsPrPC Proteinsadaptationconformational selectionprion strainsspecies barrierstransgenic mice

Identifiers

PMID28096357
PMCPMC5293081
OpenAlexW2576097146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.