ArticleProceedings of the National Academy of Sciences of the United States of America2017
Uncovering hidden variation in polyploid wheat.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 298 papers.
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Who cites it
298 citing papers in PubMed.
- Effect of high-amyloseFood & function · 2022Trial
- Increased grain weight conferred by GW2 mutations in wheat does not translate into yield gains in multi-year field trials of near-isogenic lines.Journal of experimental botany · 2026Article
- The hijacking of a wheat Exo70-like protein by a fungal pathogen triggers disease.Nature communications · 2026Article
- Phenotypic selection of high-yielding, water-productive wheat (Triticum aestivum L.) putative mutants under well-watered and limited-irrigation conditions.Scientific reports · 2026Article
- Spatial Regulation of Silicon Accumulation in Peduncle Confers Sheathed Spike in Barley.Plant biotechnology journal · 2026Article
- Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors.The New phytologist · 2026Article
- A Water-Saving Drought Survival Phenotype in a Wheat TILLING Mutant Involves Survival-Biased Metabolic and Phosphorylation Reprogramming.Plant, cell & environment · 2026Article
- Advances in mutant characterization for detecting causal mutations in crop plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Genome-Wide Identification of the WheatPlants (Basel, Switzerland) · 2026Article
- Beyond R-Genes: Dissecting Metabolic and Nutrient-Driven Wheat Rust Resistance Through Induced Mutagenesis.Plants (Basel, Switzerland) · 2026Review
- Spatial transcriptomics identifies distinct domains regulating yield-component traits of the wheat ear.Science advances · 2026Article
- VERNALIZATION2 alters early tiller development in a facultative spring hexaploid bread wheat.The New phytologist · 2026Article
- A wheat MYB transcription factor activates defense by repressing TaSIZ1 in response to branched-chain amino acid accumulation.The Plant cell · 2026Article
- A High Soluble-Fibre Allele in Wheat Encodes a Defective Cell Wall Peroxidase Responsible for Dimerization of Ferulate Moieties on Arabinoxylan.Plant biotechnology journal · 2026Article
- The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos.The New phytologist · 2026Article
- Structural and coding variation inbioRxiv : the preprint server for biology · 2026Article
- CATION AMINO ACID TRANSPORTER1 encodes an arginine transporter whose expression is influenced by daylength and Photoperiod-1.Annals of botany · 2026Article
- Starch Synthase 3 isoforms are essential for normal starch granule initiation in wheat endosperm.The New phytologist · 2026Article
- Vacuolar zinc transporter TaMTP1 safeguards wheat fertility and regulates grain zinc allocation via stem-mediated sequestration.The Plant journal : for cell and molecular biology · 2026Article
- Polyploidy and Mutagenic Germplasm Innovation in Minor Legumes: Paradigm Shift and Challenges from Model Crops to Mung Bean.Plants (Basel, Switzerland) · 2026Review
238 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
Comprehensive reverse genetic resources, which have been key to understanding gene function in diploid model organisms, are missing in many polyploid crops. Young polyploid species such as wheat, which was domesticated less than 10,000 y ago, have high levels of sequence identity among subgenomes that mask the effects of recessive alleles. Such redundancy reduces the probability of selection of favorable mutations during natural or human selection, but also allows wheat to tolerate high densities of induced mutations. Here we exploited this property to sequence and catalog more than 10 million mutations in the protein-coding regions of 2,735 mutant lines of tetraploid and hexaploid wheat. We detected, on average, 2,705 and 5,351 mutations per tetraploid and hexaploid line, respectively, which resulted in 35-40 mutations per kb in each population. With these mutation densities, we identified an average of 23-24 missense and truncation alleles per gene, with at least one truncation or deleterious missense mutation in more than 90% of the captured wheat genes per population. This public collection of mutant seed stocks and sequence data enables rapid identification of mutations in the different copies of the wheat genes, which can be combined to uncover previously hidden variation. Polyploidy is a central phenomenon in plant evolution, and many crop species have undergone recent genome duplication events. Therefore, the general strategy and methods developed herein can benefit other polyploid crops.
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