Evidence map›Paper›PMID 28096317›Full record

ReviewBioscience reports2017

Modelling the molecular mechanisms of aging.

Mark T Mc Auley, Alvaro Martinez Guimera, David Hodgson, Neil Mcdonald, Kathleen M Mooney, Amy E Morgan, Carole J Proctor

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  10. qMAP enabled microanatomical mapping of human skin aging.bioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Toxicology of pharmaceutical and nutritional longevity compounds.Expert reviews in molecular medicine · 2023
    Review
  13. Effects of fasting onHeliyon · 2023
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark T Mc AuleyFaculty of Science and Engineering, University of Chester, Chester, U.K.
Alvaro Martinez GuimeraMRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), Newcastle University, Newcastle upon Tyne, Ormskirk, U.K.
David HodgsonMRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), Newcastle University, Newcastle upon Tyne, Ormskirk, U.K.
Neil McdonaldMRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), Newcastle University, Newcastle upon Tyne, Ormskirk, U.K.
Kathleen M MooneyFaculty of Health and Social Care, Edge Hill University, U.K.
Amy E MorganFaculty of Science and Engineering, University of Chester, Chester, U.K.
Carole J ProctorMRC/Arthritis Research UK Centre for Musculoskeletal Ageing (CIMA), Newcastle University, Newcastle upon Tyne, Ormskirk, U.K. carole.proctor@ncl.ac.uk.

Funding

Arthritis Research UKMedical Research Council MR/K006312/1
6 · The paper itself

Abstract

The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process. The complexity of the aging process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards and discusses many specific examples of models that have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.

Indexed as

AgingComputer SimulationModels, BiologicalAnimalsDNA DamageDNA RepairHumansMitochondrial DynamicsProteolysisReactive Oxygen SpeciesSignal TransductionSoftwareTelomere ShorteningReactive Oxygen Speciesagingcomputational modelscomputer simulationmodelling standardsmolecular mechanisms

Identifiers

PMID28096317
PMCPMC5322748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.