Evidence map›Paper›PMID 28096161›Full record

ArticleAntimicrobial agents and chemotherapy2017

Perifosine Mechanisms of Action in Leishmania Species.

Atteneri López-Arencibia, Carmen Martín-Navarro, Ines Sifaoui, María Reyes-Batlle, Carolina Wagner, Jacob Lorenzo-Morales, Sutherland K Maciver, José E Piñero

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  4. Discovery of New Chemical Tools againstPharmaceuticals (Basel, Switzerland) · 2021
    Article
  5. Acrylonitrile Derivatives againstPharmaceuticals (Basel, Switzerland) · 2021
    Article
  6. Antimicrobial agents and chemotherapy · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Antioxidant and Leishmanicidal Evaluation ofPathogens (Basel, Switzerland) · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Atteneri López-ArencibiaCentre for Integrative Physiology, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom atlopez@ull.edu.es.
Carmen Martín-NavarroUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.
Ines SifaouiLaboratoire Matériaux-Molécules et Applications, University of Carthage, La Marsa, Tunisia.
María Reyes-BatlleUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.
Carolina WagnerUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.
Jacob Lorenzo-MoralesUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.
Sutherland K MaciverCentre for Integrative Physiology, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.
José E PiñeroUniversity Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here the mechanism by which perifosine induced cell death in

Indexed as

Adenosine TriphosphateAntiprotozoal AgentsApoptosisGene ExpressionInhibitory Concentration 50Leishmania donovaniLeishmania mexicanaMembrane Potential, MitochondrialMitochondriaPhosphatidylserinesPhosphorylationPhosphorylcholineProto-Oncogene Proteins c-aktProtozoan ProteinsAdenosine TriphosphateAntiprotozoal AgentsmiltefosineperifosinePhosphatidylserinesPhosphorylcholineProto-Oncogene Proteins c-aktProtozoan Proteinsactivityapoptosis-likeLeishmaniaperifosine

Identifiers

PMID28096161
PMCPMC5365646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.