ReviewAdvances in nutrition (Bethesda, Md.)2017
The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease.
Review in Advances in nutrition (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03625427 (Effects of Palmitoleic Acid on Circulating C-reactive Protein Levels in Humans), which is not on this map. Cited by 113 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Palmitoleic Acid on Circulating C-reactive Protein Levels in Humans
Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 249 citations in OpenAlex.
- Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review.Lipids in health and disease · 2019Pooled it
- Trial
- Effects of a palmitoleic acid concentrated oil on C-reactive protein levels in adults: A randomized, double-blind placebo-controlled clinical trial.The American journal of clinical nutrition · 2025Trial
- Macadamia nut effects on cardiometabolic risk factors: a randomised trial.Journal of nutritional science · 2023Trial
- Trial
- Supplementation with Seabuckthorn Oil Augmented in 16:1n-7t Increases Serum Trans-Palmitoleic Acid in Metabolically Healthy Adults: A Randomized Crossover Dose-Escalation Study.The Journal of nutrition · 2020Trial
- Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Trial
- Article
- Metabolite and nutrient regulation of macrophages in obesity and metabolic disease.Nature reviews. Immunology · 2026Review
- Regulatory networks involved in modulating fat deposition in pigs identified by gene co-expression analysis.BMC genomics · 2026Article
- From Nutritional Profile to Circular Bioeconomy: A Review of Sea Buckthorn Oil and By-Product Valorization.Foods (Basel, Switzerland) · 2026Review
- Reduction of palmitoleic acid due to changes in pulmonary microbiota contributes to acute lung injury after single-lung ventilation.American journal of respiratory cell and molecular biology · 2026Article
- Chemical Profiling andNutrients · 2026Article
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Palmitoleic (16:1 n-7) acid and metabolic health: integrating observational, clinical, and mechanistic evidence.Frontiers in nutrition · 2026Review
- Palmitoleic acid content and composition-based nutritional quality of commercial omega-7 oils and supplements.Frontiers in nutrition · 2026Article
- AI-Assisted Response Surface Methodology for Growth Optimization and Industrial Applicability Evaluation of the DiatomBioengineering (Basel, Switzerland) · 2025Article
- Essential oil from Tragopogon dubius selectively inhibits breast (MCF-7) and glioblastoma (LN-18) cancer cell proliferation; insights into antioxidant, genoprotective potential, and GCMS, GCGCTOFMS-based profiling.Medical oncology (Northwood, London, England) · 2025Article
- Quantity of fat consumed predisposes cardiac tissues to greater metabolic risk than their level of saturation.Scientific reports · 2025Article
- Exploring the Plasma Fatty Acid Signature of Primary Aldosteronism: Comparison with Essential Hypertension and Longitudinal Therapy Effects.Diagnostics (Basel, Switzerland) · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Although trans-palmitoleate is also synthesized in humans, it is mainly found as an exogenous source in ruminant fat and dairy products. Recently, palmitoleate was considered to be a lipokine based on evidence demonstrating its release from adipose tissue and its metabolic effects on distant organs. After this finding, research has been performed to determine whether palmitoleate has beneficial effects on metabolism and to elucidate the underlying mechanisms. Thus, the aim of this work was to review the current status of knowledge about palmitoleate, its metabolism, and its influence on metabolic abnormalities. Results have shown mixed cardiovascular effects, direct or inverse correlations with obesity, and hepatosteatosis, but a significant amelioration or prevention of insulin resistance and diabetes. Finally, the induction of palmitoleate release from adipose tissue, dietary intake, and its supplementation are all interventions with a potential impact on certain metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.