Evidence map›Paper›PMID 28096129›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2017

Current Knowledge of Necrotizing Enterocolitis in Preterm Infants and the Impact of Different Types of Enteral Nutrition Products.

Jocelyn Shulhan, Bryan Dicken, Lisa Hartling, Bodil Mk Larsen

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03700957 (A Clinical Study on the Impact of Docosahexaenoic Acid on the Prevention of Necrotizing Enterocolitis in Preterm Neonates), which is not on this map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03700957 naunknown statusnot on this mapstarted 2018, after this paper: background citation

A Clinical Study on the Impact of Docosahexaenoic Acid on the Prevention of Necrotizing Enterocolitis in Preterm Neonates

TypeinterventionalSponsorAin Shams UniversityRan2018 to 2019Enrolled60ConditionsNecrotizing EnterocolitisArmsDocosahexaenoic Acid, placebo
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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  5. Nutrient-enriched formula versus standard formula for preterm infants.The Cochrane database of systematic reviews · 2019
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Jocelyn ShulhanDepartments of Pediatrics and jshulhan@ualberta.ca.ORCID 0000-0001-7623-2674
Bryan DickenSurgery, Faculty of Medicine and Dentistry, and.
Lisa HartlingDepartments of Pediatrics and.
Bodil Mk LarsenDepartments of Pediatrics and.ORCID 0000-0003-2069-636X
University of Alberta · CAAlberta Health Services · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm infants are extremely vulnerable to a range of morbidities and mortality. Underdeveloped cardiac, respiratory, gastrointestinal, and immune systems in the preterm period increase the risk of necrotizing enterocolitis (NEC), a serious disease of the gut. NEC affects 5-12% of very-low birth-weight infants, leads to surgery in 20-40% of cases, and is fatal in 25-50% of cases. There are multiple factors that may contribute to NEC, but the exact cause is not yet fully understood. Severe cases can result in intestinal resection or death, and the health care costs average >$300,000/infant when surgical management is required. Different types of nutrition may affect the onset or progression of NEC. Several studies have indicated that bovine milk-based infant formulas lead to a higher incidence of NEC in preterm infants than does human milk (HM). However, it is not clear why HM is linked to a lower incidence of NEC or why some infants fed an exclusively HM diet still develop NEC. An area that has not been thoroughly explored is the use of semielemental or elemental formulas. These specialty formulas are easy to digest and absorb in the gut and may be an effective nutritional intervention for reducing the risk of NEC. This review summarizes what is known about the factors that contribute to the onset and progression of NEC, discusses its health care cost implications, and explores the impact that different formulas and HM have on this disease.

Indexed as

AnimalsDisease ManagementEnteral NutritionEnterocolitis, NecrotizingHumansInfantInfant FormulaInfant, PrematureInfant, Very Low Birth WeightMeta-Analysis as TopicMilkMilk, HumanRandomized Controlled Trials as Topicbreast milkelemental formulaformulahydrolyzed formulanecrotizing enterocolitisnutritionpreterm infantsemielemental formula

Identifiers

PMID28096129
PMCPMC5227976
OpenAlexW2577908951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.